Glycoarrays - Tools for determining protein-carbohydrate interactions and glycoenzyme specificity

Nicolas Laurent, Josef Voglmeir, Sabine L. Flitsch

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Carbohydrate arrays (glycoarrays) have recently emerged as a high-throughput tool for studying carbohydrate-binding proteins and carbohydrate-processing enzymes. A number of sophisticated array platforms that allow for qualitative and quantitative analysis of carbohydrate binding and modification on the array surface have been developed, including analysis by fluorescence spectroscopy, mass spectrometry and surface plasmon resonance spectroscopy. These platforms, together with examples of biologically-relevant applications are reviewed in this Feature Article. © The Royal Society of Chemistry.
    Original languageEnglish
    Pages (from-to)4400-4412
    Number of pages12
    JournalChemical Communications
    Issue number37
    DOIs
    Publication statusPublished - 2008

    Keywords

    • SELF-ASSEMBLED MONOLAYERS
    • SURFACE-PLASMON RESONANCE
    • OLIGOSACCHARIDE
    • PROBES NEOGLYCOLIPIDS
    • GLYCAN-BINDING-PROTEINS
    • PLANT-CELL WALLS
    • LABEL-FREE
    • CHEMOENZYMATIC SYNTHESIS
    • ENZYMATIC GLYCOSYLATION
    • MICROARRAY ANALYSIS
    • INFLUENZA-VIRUSES

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