Abstract
Carbohydrate arrays (glycoarrays) have recently emerged as a high-throughput tool for studying carbohydrate-binding proteins and carbohydrate-processing enzymes. A number of sophisticated array platforms that allow for qualitative and quantitative analysis of carbohydrate binding and modification on the array surface have been developed, including analysis by fluorescence spectroscopy, mass spectrometry and surface plasmon resonance spectroscopy. These platforms, together with examples of biologically-relevant applications are reviewed in this Feature Article. © The Royal Society of Chemistry.
Original language | English |
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Pages (from-to) | 4400-4412 |
Number of pages | 12 |
Journal | Chemical Communications |
Issue number | 37 |
DOIs | |
Publication status | Published - 2008 |
Keywords
- SELF-ASSEMBLED MONOLAYERS
- SURFACE-PLASMON RESONANCE
- OLIGOSACCHARIDE
- PROBES NEOGLYCOLIPIDS
- GLYCAN-BINDING-PROTEINS
- PLANT-CELL WALLS
- LABEL-FREE
- CHEMOENZYMATIC SYNTHESIS
- ENZYMATIC GLYCOSYLATION
- MICROARRAY ANALYSIS
- INFLUENZA-VIRUSES