Golgins and GRASPs: Holding the Golgi together

Irene Barinaga-Rementeria Ramirez; Martin Lowe

doi:10.1016/j.semcdb.2009.03.011

Golgins and GRASPs: Holding the Golgi together

Irene Barinaga-Rementeria Ramirez, Martin Lowe

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Abstract

The GRASP and golgin families of proteins have emerged as key components of the Golgi apparatus, with major roles in both the structural organisation of this organelle and the trafficking that occurs there. Both types of protein participate in membrane tethering events that occur upstream of membrane fusion as well as contributing to the structural scaffold that defines Golgi architecture, referred to as the Golgi matrix. The importance of these proteins is highlighted by their targeting in mitosis, apoptosis, and pathogenic infections that cause dramatic structural and functional reorganisation of the Golgi apparatus. In this review we will discuss our current understanding of GRASP and golgin function, highlighting some of the common themes that have emerged as well as describing previously unsuspected roles for these proteins in various cellular processes. © 2009 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	770-779
Number of pages	9
Journal	Seminars in Cell and Developmental Biology
Volume	20
Issue number	7
DOIs	https://doi.org/10.1016/j.semcdb.2009.03.011
Publication status	Published - Sept 2009

Keywords

Golgi matrix
Golgi structure
Golgin
GRASP
Tethering

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10.1016/j.semcdb.2009.03.011

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title = "Golgins and GRASPs: Holding the Golgi together",

abstract = "The GRASP and golgin families of proteins have emerged as key components of the Golgi apparatus, with major roles in both the structural organisation of this organelle and the trafficking that occurs there. Both types of protein participate in membrane tethering events that occur upstream of membrane fusion as well as contributing to the structural scaffold that defines Golgi architecture, referred to as the Golgi matrix. The importance of these proteins is highlighted by their targeting in mitosis, apoptosis, and pathogenic infections that cause dramatic structural and functional reorganisation of the Golgi apparatus. In this review we will discuss our current understanding of GRASP and golgin function, highlighting some of the common themes that have emerged as well as describing previously unsuspected roles for these proteins in various cellular processes. {\textcopyright} 2009 Elsevier Ltd. All rights reserved.",

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author = "{Barinaga-Rementeria Ramirez}, Irene and Martin Lowe",

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AU - Lowe, Martin

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AB - The GRASP and golgin families of proteins have emerged as key components of the Golgi apparatus, with major roles in both the structural organisation of this organelle and the trafficking that occurs there. Both types of protein participate in membrane tethering events that occur upstream of membrane fusion as well as contributing to the structural scaffold that defines Golgi architecture, referred to as the Golgi matrix. The importance of these proteins is highlighted by their targeting in mitosis, apoptosis, and pathogenic infections that cause dramatic structural and functional reorganisation of the Golgi apparatus. In this review we will discuss our current understanding of GRASP and golgin function, highlighting some of the common themes that have emerged as well as describing previously unsuspected roles for these proteins in various cellular processes. © 2009 Elsevier Ltd. All rights reserved.

KW - Golgi matrix

KW - Golgi structure

KW - Golgin

KW - GRASP

KW - Tethering

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DO - 10.1016/j.semcdb.2009.03.011

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EP - 779

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

IS - 7

ER -

Golgins and GRASPs: Holding the Golgi together

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Keywords

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