Gout and hyperuricaemia in adults with cystic fibrosis

Alex Horsley; Jennifer Helm; Amanda Brennan; Rowland Bright-Thomas; Kevin Webb; Andrew Jones

doi:10.1258/jrsm.2011.s11106

Gout and hyperuricaemia in adults with cystic fibrosis

Alex Horsley, Jennifer Helm, Amanda Brennan, Rowland Bright-Thomas, Kevin Webb, Andrew Jones

Research output: Contribution to journal › Article › peer-review

Abstract

Gout has not been described previously as a complication in cystic fibrosis (CF). Here we present data on nine CF patients who have presented with symptoms of acute gout. This gives an estimated prevalence of gout of around 2.5% in our adult CF population, compared to a previously described prevalence in the non-CF population of just over 1%. Serum urate is measured routinely at the annual review in our unit. Mean (SD) serumurate was 0.40 (0.09)mmol/L inmaleCFpatients (n=108) and 0.31 (0.08)mmol/L in female patients (n=74). This was significantly greater than in historical controls. Thirty-seven percent of male CF patients and 36% of female patients had serum urate levels above the upper limit of normal.

Original language	English
Pages (from-to)	S36-S39
Journal	Royal Society of Medicine. Journal. Supplement
Volume	104
Issue number	1
DOIs	https://doi.org/10.1258/jrsm.2011.s11106
Publication status	Published - Jul 2011

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title = "Gout and hyperuricaemia in adults with cystic fibrosis",

abstract = "Gout has not been described previously as a complication in cystic fibrosis (CF). Here we present data on nine CF patients who have presented with symptoms of acute gout. This gives an estimated prevalence of gout of around 2.5% in our adult CF population, compared to a previously described prevalence in the non-CF population of just over 1%. Serum urate is measured routinely at the annual review in our unit. Mean (SD) serumurate was 0.40 (0.09)mmol/L inmaleCFpatients (n=108) and 0.31 (0.08)mmol/L in female patients (n=74). This was significantly greater than in historical controls. Thirty-seven percent of male CF patients and 36% of female patients had serum urate levels above the upper limit of normal.",

author = "Alex Horsley and Jennifer Helm and Amanda Brennan and Rowland Bright-Thomas and Kevin Webb and Andrew Jones",

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T1 - Gout and hyperuricaemia in adults with cystic fibrosis

AU - Horsley, Alex

AU - Helm, Jennifer

AU - Brennan, Amanda

AU - Bright-Thomas, Rowland

AU - Webb, Kevin

AU - Jones, Andrew

PY - 2011/7

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N2 - Gout has not been described previously as a complication in cystic fibrosis (CF). Here we present data on nine CF patients who have presented with symptoms of acute gout. This gives an estimated prevalence of gout of around 2.5% in our adult CF population, compared to a previously described prevalence in the non-CF population of just over 1%. Serum urate is measured routinely at the annual review in our unit. Mean (SD) serumurate was 0.40 (0.09)mmol/L inmaleCFpatients (n=108) and 0.31 (0.08)mmol/L in female patients (n=74). This was significantly greater than in historical controls. Thirty-seven percent of male CF patients and 36% of female patients had serum urate levels above the upper limit of normal.

AB - Gout has not been described previously as a complication in cystic fibrosis (CF). Here we present data on nine CF patients who have presented with symptoms of acute gout. This gives an estimated prevalence of gout of around 2.5% in our adult CF population, compared to a previously described prevalence in the non-CF population of just over 1%. Serum urate is measured routinely at the annual review in our unit. Mean (SD) serumurate was 0.40 (0.09)mmol/L inmaleCFpatients (n=108) and 0.31 (0.08)mmol/L in female patients (n=74). This was significantly greater than in historical controls. Thirty-seven percent of male CF patients and 36% of female patients had serum urate levels above the upper limit of normal.

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DO - 10.1258/jrsm.2011.s11106

M3 - Article

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VL - 104

SP - S36-S39

JO - Royal Society of Medicine. Journal. Supplement

JF - Royal Society of Medicine. Journal. Supplement

IS - 1

ER -

Gout and hyperuricaemia in adults with cystic fibrosis

Abstract

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