Gray matter nulled and vascular space occupancy dependent fMRI response to visual stimulation during hypoxic hypoxia

Yuji Shen; Yi Ching L Ho; Rishma Vidyasagar; George Balanos; Xavier Golay; Ida M. Pu; Risto A. Kauppinen

doi:10.1016/j.neuroimage.2011.10.097

Gray matter nulled and vascular space occupancy dependent fMRI response to visual stimulation during hypoxic hypoxia

Yuji Shen, Yi Ching L Ho, Rishma Vidyasagar, George Balanos, Xavier Golay, Ida M. Pu, Risto A. Kauppinen

Research output: Contribution to journal › Article › peer-review

Abstract

Two cerebral blood volume (CBV)-weighted fMRI techniques, gray matter nulled (GMN) and vascular space occupancy (VASO)-dependent techniques at spatial resolution of 2×2×5mm 3, were compared in the study investigating functional responses in the human visual cortex to stimulation in normoxia (inspired O 2=21%) and mild hypoxic hypoxia (inspired O 2=12%). GMN and VASO signals and T 2* were quantified in activated voxels. While the CBV-weighted signal changes in voxels activated by visual stimulation were similar in amplitude in both fMRI techniques in both oxygenation conditions, the number of activated voxels during hypoxic hypoxia was significantly reduced by 72±22% in GMN fMRI and 66±23% in VASO fMRI. T 2* prolonged in GMN and VASO activated voxels in normoxia by 1.6±0.5ms and 1.7±0.5ms, respectively. In hypoxia, however, T 2* shortened in GMN-activated voxels by 0.7±0.6ms (p

Original language	English
Pages (from-to)	3450-3456
Number of pages	6
Journal	NeuroImage
Volume	59
Issue number	4
DOIs	https://doi.org/10.1016/j.neuroimage.2011.10.097
Publication status	Published - 15 Feb 2012

Keywords

BOLD
FMRI
GMN
VASO

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10.1016/j.neuroimage.2011.10.097

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title = "Gray matter nulled and vascular space occupancy dependent fMRI response to visual stimulation during hypoxic hypoxia",

abstract = "Two cerebral blood volume (CBV)-weighted fMRI techniques, gray matter nulled (GMN) and vascular space occupancy (VASO)-dependent techniques at spatial resolution of 2×2×5mm 3, were compared in the study investigating functional responses in the human visual cortex to stimulation in normoxia (inspired O 2=21%) and mild hypoxic hypoxia (inspired O 2=12%). GMN and VASO signals and T 2* were quantified in activated voxels. While the CBV-weighted signal changes in voxels activated by visual stimulation were similar in amplitude in both fMRI techniques in both oxygenation conditions, the number of activated voxels during hypoxic hypoxia was significantly reduced by 72±22% in GMN fMRI and 66±23% in VASO fMRI. T 2* prolonged in GMN and VASO activated voxels in normoxia by 1.6±0.5ms and 1.7±0.5ms, respectively. In hypoxia, however, T 2* shortened in GMN-activated voxels by 0.7±0.6ms (p",

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author = "Yuji Shen and Ho, {Yi Ching L} and Rishma Vidyasagar and George Balanos and Xavier Golay and Pu, {Ida M.} and Kauppinen, {Risto A.}",

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AU - Shen, Yuji

AU - Ho, Yi Ching L

AU - Vidyasagar, Rishma

AU - Balanos, George

AU - Golay, Xavier

AU - Pu, Ida M.

AU - Kauppinen, Risto A.

N1 - Times Cited: 0

PY - 2012/2/15

Y1 - 2012/2/15

N2 - Two cerebral blood volume (CBV)-weighted fMRI techniques, gray matter nulled (GMN) and vascular space occupancy (VASO)-dependent techniques at spatial resolution of 2×2×5mm 3, were compared in the study investigating functional responses in the human visual cortex to stimulation in normoxia (inspired O 2=21%) and mild hypoxic hypoxia (inspired O 2=12%). GMN and VASO signals and T 2* were quantified in activated voxels. While the CBV-weighted signal changes in voxels activated by visual stimulation were similar in amplitude in both fMRI techniques in both oxygenation conditions, the number of activated voxels during hypoxic hypoxia was significantly reduced by 72±22% in GMN fMRI and 66±23% in VASO fMRI. T 2* prolonged in GMN and VASO activated voxels in normoxia by 1.6±0.5ms and 1.7±0.5ms, respectively. In hypoxia, however, T 2* shortened in GMN-activated voxels by 0.7±0.6ms (p

AB - Two cerebral blood volume (CBV)-weighted fMRI techniques, gray matter nulled (GMN) and vascular space occupancy (VASO)-dependent techniques at spatial resolution of 2×2×5mm 3, were compared in the study investigating functional responses in the human visual cortex to stimulation in normoxia (inspired O 2=21%) and mild hypoxic hypoxia (inspired O 2=12%). GMN and VASO signals and T 2* were quantified in activated voxels. While the CBV-weighted signal changes in voxels activated by visual stimulation were similar in amplitude in both fMRI techniques in both oxygenation conditions, the number of activated voxels during hypoxic hypoxia was significantly reduced by 72±22% in GMN fMRI and 66±23% in VASO fMRI. T 2* prolonged in GMN and VASO activated voxels in normoxia by 1.6±0.5ms and 1.7±0.5ms, respectively. In hypoxia, however, T 2* shortened in GMN-activated voxels by 0.7±0.6ms (p

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KW - VASO

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JO - NeuroImage

JF - NeuroImage

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ER -

Gray matter nulled and vascular space occupancy dependent fMRI response to visual stimulation during hypoxic hypoxia

Abstract

Keywords

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