Growth hormone signalling: sprouting links between pathways, human genetics and therapeutic options

Iwona Pilecka; Andrew Whatmore; Rob Hooft van Huijsduijnen; Benoit Destenaves; Peter Clayton

doi:10.1016/j.tem.2006.11.004

Growth hormone signalling: sprouting links between pathways, human genetics and therapeutic options

Iwona Pilecka, Andrew Whatmore, Rob Hooft van Huijsduijnen, Benoit Destenaves, Peter Clayton

Research output: Contribution to journal › Article › peer-review

Abstract

Our molecular understanding of growth hormone-induced signal transduction has improved significantly over the past decades. At the same time, human population genetics and the analysis of genetically engineered animals have led to the discovery of genes that control specific aspects of the overall growth process. Although, currently, growth disorders are still diagnosed and treated on empirical bases, it might soon be possible to stratify patients predominantly by genetic defect, with treatment based on our molecular understanding of the role of the affected gene in the disease. © 2006 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	12-18
Number of pages	6
Journal	Trends in Endocrinology and Metabolism
Volume	18
Issue number	1
DOIs	https://doi.org/10.1016/j.tem.2006.11.004
Publication status	Published - Jan 2007

Keywords

Animals
genetics: Growth Disorders
physiology: Growth Hormone
Humans
Models, Biological
physiology: Receptors, Somatotropin
physiology: Signal Transduction

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10.1016/j.tem.2006.11.004

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abstract = "Our molecular understanding of growth hormone-induced signal transduction has improved significantly over the past decades. At the same time, human population genetics and the analysis of genetically engineered animals have led to the discovery of genes that control specific aspects of the overall growth process. Although, currently, growth disorders are still diagnosed and treated on empirical bases, it might soon be possible to stratify patients predominantly by genetic defect, with treatment based on our molecular understanding of the role of the affected gene in the disease. {\textcopyright} 2006 Elsevier Ltd. All rights reserved.",

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AU - Pilecka, Iwona

AU - Whatmore, Andrew

AU - van Huijsduijnen, Rob Hooft

AU - Destenaves, Benoit

AU - Clayton, Peter

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AB - Our molecular understanding of growth hormone-induced signal transduction has improved significantly over the past decades. At the same time, human population genetics and the analysis of genetically engineered animals have led to the discovery of genes that control specific aspects of the overall growth process. Although, currently, growth disorders are still diagnosed and treated on empirical bases, it might soon be possible to stratify patients predominantly by genetic defect, with treatment based on our molecular understanding of the role of the affected gene in the disease. © 2006 Elsevier Ltd. All rights reserved.

KW - Animals

KW - genetics: Growth Disorders

KW - physiology: Growth Hormone

KW - Humans

KW - Models, Biological

KW - physiology: Receptors, Somatotropin

KW - physiology: Signal Transduction

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M3 - Article

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JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 1

ER -

Growth hormone signalling: sprouting links between pathways, human genetics and therapeutic options

Abstract

Keywords

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