Growth response to growth hormone therapy following craniospinal irradiation

P. E. Clayton; S. M. Shalet; D. A. Price

doi:10.1007/BF00442471

Growth response to growth hormone therapy following craniospinal irradiation

P. E. Clayton, S. M. Shalet, D. A. Price

Research output: Contribution to journal › Article › peer-review

Abstract

Nineteen (12 male, 7 female) children, who have received craniospinal irradiation for the treatment of a brain tumour distant from the hypothalamic-pituitary axis, resulting in growth hormone (GH) deficiency (CS-PRGHD), have been treated with GH. Eight have completed growth. Comparison has been made with the growth of seven untreated children, whose heights and growth rates at presentation were normal despite GH deficiency secondary to irradiation. GH produced a significant increase in growth velocity over the first 3 years' treatment in CS-PRGHD patients with a mean first year increment of 3 cm/year. Patients, treated to completion of growth, showed a significant increase in leg length standard deviation (SD) score (ΔSDS+0.2) compared to that of the untreated (ΔSDS-0.9) (P

Original language	English
Pages (from-to)	597-601
Number of pages	4
Journal	European Journal of Pediatrics
Volume	147
Issue number	6
DOIs	https://doi.org/10.1007/BF00442471
Publication status	Published - Aug 1988

Keywords

Brain tumours
Craniospinal irradiation
Growth hormone

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10.1007/BF00442471

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title = "Growth response to growth hormone therapy following craniospinal irradiation",

abstract = "Nineteen (12 male, 7 female) children, who have received craniospinal irradiation for the treatment of a brain tumour distant from the hypothalamic-pituitary axis, resulting in growth hormone (GH) deficiency (CS-PRGHD), have been treated with GH. Eight have completed growth. Comparison has been made with the growth of seven untreated children, whose heights and growth rates at presentation were normal despite GH deficiency secondary to irradiation. GH produced a significant increase in growth velocity over the first 3 years' treatment in CS-PRGHD patients with a mean first year increment of 3 cm/year. Patients, treated to completion of growth, showed a significant increase in leg length standard deviation (SD) score (ΔSDS+0.2) compared to that of the untreated (ΔSDS-0.9) (P",

keywords = "Brain tumours, Craniospinal irradiation, Growth hormone",

author = "Clayton, {P. E.} and Shalet, {S. M.} and Price, {D. A.}",

year = "1988",

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T1 - Growth response to growth hormone therapy following craniospinal irradiation

AU - Clayton, P. E.

AU - Shalet, S. M.

AU - Price, D. A.

PY - 1988/8

Y1 - 1988/8

N2 - Nineteen (12 male, 7 female) children, who have received craniospinal irradiation for the treatment of a brain tumour distant from the hypothalamic-pituitary axis, resulting in growth hormone (GH) deficiency (CS-PRGHD), have been treated with GH. Eight have completed growth. Comparison has been made with the growth of seven untreated children, whose heights and growth rates at presentation were normal despite GH deficiency secondary to irradiation. GH produced a significant increase in growth velocity over the first 3 years' treatment in CS-PRGHD patients with a mean first year increment of 3 cm/year. Patients, treated to completion of growth, showed a significant increase in leg length standard deviation (SD) score (ΔSDS+0.2) compared to that of the untreated (ΔSDS-0.9) (P

AB - Nineteen (12 male, 7 female) children, who have received craniospinal irradiation for the treatment of a brain tumour distant from the hypothalamic-pituitary axis, resulting in growth hormone (GH) deficiency (CS-PRGHD), have been treated with GH. Eight have completed growth. Comparison has been made with the growth of seven untreated children, whose heights and growth rates at presentation were normal despite GH deficiency secondary to irradiation. GH produced a significant increase in growth velocity over the first 3 years' treatment in CS-PRGHD patients with a mean first year increment of 3 cm/year. Patients, treated to completion of growth, showed a significant increase in leg length standard deviation (SD) score (ΔSDS+0.2) compared to that of the untreated (ΔSDS-0.9) (P

KW - Brain tumours

KW - Craniospinal irradiation

KW - Growth hormone

U2 - 10.1007/BF00442471

DO - 10.1007/BF00442471

M3 - Article

SN - 0340-6199

VL - 147

SP - 597

EP - 601

JO - European Journal of Pediatrics

JF - European Journal of Pediatrics

IS - 6

ER -

Growth response to growth hormone therapy following craniospinal irradiation

Abstract

Keywords

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