GTF2IRD1 regulates transcription by binding an evolutionarily conserved DNA motif 'GUCE'

P. D. Thompson; M. Webb; W. Beckett; T. Hinsley; T. Jowitt; A. D. Sharrocks; M. Tassabehji

doi:10.1016/j.febslet.2007.02.040

GTF2IRD1 regulates transcription by binding an evolutionarily conserved DNA motif 'GUCE'

P. D. Thompson, M. Webb, W. Beckett, T. Hinsley, T. Jowitt, A. D. Sharrocks, M. Tassabehji

Research output: Contribution to journal › Article › peer-review

Abstract

GTF2IRD1 is a member of a family of transcription factors whose defining characteristic is varying numbers of a helix-loop-helix like motif, the I-repeat. Here, we present functional analysis of human GTF2IRD1 in regulation of three genes (HOXC8, GOOSECOID and TROPONIN ISLOW). We define a regulatory motif (GUCE-GTF2IRD1 Upstream Control Element) common to all three genes. GUCE is bound in vitro by domain I-4 of GTF2IRD1 and mediates transcriptional regulation by GTF2IRD1 in vivo. Definition of this site will assist in identification of other downstream targets of GTF2IRD1 and elucidation of its role in the human developmental disorder Williams-Beuren syndrome. © 2007 Federation of European Biochemical Societies.

Original language	English
Pages (from-to)	1233-1242
Number of pages	9
Journal	FEBS Letters
Volume	581
Issue number	6
DOIs	https://doi.org/10.1016/j.febslet.2007.02.040
Publication status	Published - 20 Mar 2007

Keywords

DNA binding
GTF2IRD1
GUCE
isoforms
TFII-I
Transcription regulation
Williams-Beuren syndrome

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10.1016/j.febslet.2007.02.040

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title = "GTF2IRD1 regulates transcription by binding an evolutionarily conserved DNA motif 'GUCE'",

abstract = "GTF2IRD1 is a member of a family of transcription factors whose defining characteristic is varying numbers of a helix-loop-helix like motif, the I-repeat. Here, we present functional analysis of human GTF2IRD1 in regulation of three genes (HOXC8, GOOSECOID and TROPONIN ISLOW). We define a regulatory motif (GUCE-GTF2IRD1 Upstream Control Element) common to all three genes. GUCE is bound in vitro by domain I-4 of GTF2IRD1 and mediates transcriptional regulation by GTF2IRD1 in vivo. Definition of this site will assist in identification of other downstream targets of GTF2IRD1 and elucidation of its role in the human developmental disorder Williams-Beuren syndrome. {\textcopyright} 2007 Federation of European Biochemical Societies.",

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T1 - GTF2IRD1 regulates transcription by binding an evolutionarily conserved DNA motif 'GUCE'

AU - Thompson, P. D.

AU - Webb, M.

AU - Beckett, W.

AU - Hinsley, T.

AU - Jowitt, T.

AU - Sharrocks, A. D.

AU - Tassabehji, M.

PY - 2007/3/20

Y1 - 2007/3/20

N2 - GTF2IRD1 is a member of a family of transcription factors whose defining characteristic is varying numbers of a helix-loop-helix like motif, the I-repeat. Here, we present functional analysis of human GTF2IRD1 in regulation of three genes (HOXC8, GOOSECOID and TROPONIN ISLOW). We define a regulatory motif (GUCE-GTF2IRD1 Upstream Control Element) common to all three genes. GUCE is bound in vitro by domain I-4 of GTF2IRD1 and mediates transcriptional regulation by GTF2IRD1 in vivo. Definition of this site will assist in identification of other downstream targets of GTF2IRD1 and elucidation of its role in the human developmental disorder Williams-Beuren syndrome. © 2007 Federation of European Biochemical Societies.

AB - GTF2IRD1 is a member of a family of transcription factors whose defining characteristic is varying numbers of a helix-loop-helix like motif, the I-repeat. Here, we present functional analysis of human GTF2IRD1 in regulation of three genes (HOXC8, GOOSECOID and TROPONIN ISLOW). We define a regulatory motif (GUCE-GTF2IRD1 Upstream Control Element) common to all three genes. GUCE is bound in vitro by domain I-4 of GTF2IRD1 and mediates transcriptional regulation by GTF2IRD1 in vivo. Definition of this site will assist in identification of other downstream targets of GTF2IRD1 and elucidation of its role in the human developmental disorder Williams-Beuren syndrome. © 2007 Federation of European Biochemical Societies.

KW - DNA binding

KW - GTF2IRD1

KW - GUCE

KW - isoforms

KW - TFII-I

KW - Transcription regulation

KW - Williams-Beuren syndrome

U2 - 10.1016/j.febslet.2007.02.040

DO - 10.1016/j.febslet.2007.02.040

M3 - Article

C2 - 17346708

VL - 581

SP - 1233

EP - 1242

JO - FEBS Letters

JF - FEBS Letters

IS - 6

ER -

GTF2IRD1 regulates transcription by binding an evolutionarily conserved DNA motif 'GUCE'

Abstract

Keywords

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