Guidelines for clinical trials of frontal fibrosing alopecia: consensus recommendations from the International FFA Cooperative Group (IFFACG)*

E. A. Olsen; M. Harries; A. Tosti; W. Bergfeld; U. Blume-Peytavi; V. Callender; V. Chasapi; O. Correia; G. Cotsarelis; R. Dhurat; N. Dlova; I. Doche; N. Enechukwu; R. Grimalt; S. Itami; M. Hordinsky; K. Khobzei; W. S. Lee; S. Malakar; A. Messenger; A. McMichael; P. Mirmirani; Y. Ovcharenko; S. Papanikou; G. M. Pinto; B. M. Piraccini; R. Pirmez; P. Reygagne; J. Roberts; L. Rudnicka; D. Saceda-Corralo; J. Shapiro; T. Silyuk; R. Sinclair; R. O. Soares; A. Souissi; A. Vogt; K. Washenik; A. Zlotogorski; D. Canfield; S. Vano-Galvan

doi:10.1111/bjd.20567

Guidelines for clinical trials of frontal fibrosing alopecia: consensus recommendations from the International FFA Cooperative Group (IFFACG)*

E. A. Olsen^*, M. Harries, A. Tosti, W. Bergfeld, U. Blume-Peytavi, V. Callender, V. Chasapi, O. Correia, G. Cotsarelis, R. Dhurat, N. Dlova, I. Doche, N. Enechukwu, R. Grimalt, S. Itami, M. Hordinsky, K. Khobzei, W. S. Lee, S. Malakar, A. MessengerA. McMichael, P. Mirmirani, Y. Ovcharenko, S. Papanikou, G. M. Pinto, B. M. Piraccini, R. Pirmez, P. Reygagne, J. Roberts, L. Rudnicka, D. Saceda-Corralo, J. Shapiro, T. Silyuk, R. Sinclair, R. O. Soares, A. Souissi, A. Vogt, K. Washenik, A. Zlotogorski, D. Canfield, S. Vano-Galvan

^*Corresponding author for this work

Division of Musculoskeletal & Dermatological Sciences (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Frontal fibrosing alopecia (FFA) has become one of the most common causes of cicatricial alopecia worldwide. However, there is a lack of clear aetiology and robust clinical trial evidence for the efficacy and safety of agents currently used for treatment. Objectives: To enable data to be collected worldwide on FFA using common criteria and assessment methods. Methods: A multicentre, international group of experts in hair loss was convened by email to create consensus recommendations for clinical trials. Consensus was defined at > 90% agreement on each recommended part of these guidelines. Results: Standardized diagnostic criteria, severity rating, staging, and investigator and patient assessment of scalp hair loss and other clinical features of FFA were created. Conclusions: These guidelines should allow the collection of reliable aggregate data on FFA and advance efforts in both clinical and basic research to close knowledge gaps in this condition.

Original language	English
Pages (from-to)	1221-1231
Number of pages	11
Journal	British Journal of Dermatology
Volume	185
Issue number	6
DOIs	https://doi.org/10.1111/bjd.20567
Publication status	Published - Dec 2021

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10.1111/bjd.20567

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Olsen, E. A., Harries, M., Tosti, A., Bergfeld, W., Blume-Peytavi, U., Callender, V., Chasapi, V., Correia, O., Cotsarelis, G., Dhurat, R., Dlova, N., Doche, I., Enechukwu, N., Grimalt, R., Itami, S., Hordinsky, M., Khobzei, K., Lee, W. S., Malakar, S., ... Vano-Galvan, S. (2021). Guidelines for clinical trials of frontal fibrosing alopecia: consensus recommendations from the International FFA Cooperative Group (IFFACG)*. British Journal of Dermatology, 185(6), 1221-1231. https://doi.org/10.1111/bjd.20567

@article{33a9517de13640c6842fe19cec057457,

title = "Guidelines for clinical trials of frontal fibrosing alopecia: consensus recommendations from the International FFA Cooperative Group (IFFACG)*",

abstract = "Background: Frontal fibrosing alopecia (FFA) has become one of the most common causes of cicatricial alopecia worldwide. However, there is a lack of clear aetiology and robust clinical trial evidence for the efficacy and safety of agents currently used for treatment. Objectives: To enable data to be collected worldwide on FFA using common criteria and assessment methods. Methods: A multicentre, international group of experts in hair loss was convened by email to create consensus recommendations for clinical trials. Consensus was defined at > 90% agreement on each recommended part of these guidelines. Results: Standardized diagnostic criteria, severity rating, staging, and investigator and patient assessment of scalp hair loss and other clinical features of FFA were created. Conclusions: These guidelines should allow the collection of reliable aggregate data on FFA and advance efforts in both clinical and basic research to close knowledge gaps in this condition.",

author = "Olsen, {E. A.} and M. Harries and A. Tosti and W. Bergfeld and U. Blume-Peytavi and V. Callender and V. Chasapi and O. Correia and G. Cotsarelis and R. Dhurat and N. Dlova and I. Doche and N. Enechukwu and R. Grimalt and S. Itami and M. Hordinsky and K. Khobzei and Lee, {W. S.} and S. Malakar and A. Messenger and A. McMichael and P. Mirmirani and Y. Ovcharenko and S. Papanikou and Pinto, {G. M.} and Piraccini, {B. M.} and R. Pirmez and P. Reygagne and J. Roberts and L. Rudnicka and D. Saceda-Corralo and J. Shapiro and T. Silyuk and R. Sinclair and Soares, {R. O.} and A. Souissi and A. Vogt and K. Washenik and A. Zlotogorski and D. Canfield and S. Vano-Galvan",

note = "Publisher Copyright: {\textcopyright} 2021 British Association of Dermatologists",

year = "2021",

month = dec,

doi = "10.1111/bjd.20567",

language = "English",

volume = "185",

pages = "1221--1231",

journal = "British Journal of Dermatology",

issn = "0007-0963",

publisher = "Oxford University Press",

number = "6",

}

Olsen, EA, Harries, M, Tosti, A, Bergfeld, W, Blume-Peytavi, U, Callender, V, Chasapi, V, Correia, O, Cotsarelis, G, Dhurat, R, Dlova, N, Doche, I, Enechukwu, N, Grimalt, R, Itami, S, Hordinsky, M, Khobzei, K, Lee, WS, Malakar, S, Messenger, A, McMichael, A, Mirmirani, P, Ovcharenko, Y, Papanikou, S, Pinto, GM, Piraccini, BM, Pirmez, R, Reygagne, P, Roberts, J, Rudnicka, L, Saceda-Corralo, D, Shapiro, J, Silyuk, T, Sinclair, R, Soares, RO, Souissi, A, Vogt, A, Washenik, K, Zlotogorski, A, Canfield, D & Vano-Galvan, S 2021, 'Guidelines for clinical trials of frontal fibrosing alopecia: consensus recommendations from the International FFA Cooperative Group (IFFACG)*', British Journal of Dermatology, vol. 185, no. 6, pp. 1221-1231. https://doi.org/10.1111/bjd.20567

TY - JOUR

T1 - Guidelines for clinical trials of frontal fibrosing alopecia

T2 - consensus recommendations from the International FFA Cooperative Group (IFFACG)*

AU - Olsen, E. A.

AU - Harries, M.

AU - Tosti, A.

AU - Bergfeld, W.

AU - Blume-Peytavi, U.

AU - Callender, V.

AU - Chasapi, V.

AU - Correia, O.

AU - Cotsarelis, G.

AU - Dhurat, R.

AU - Dlova, N.

AU - Doche, I.

AU - Enechukwu, N.

AU - Grimalt, R.

AU - Itami, S.

AU - Hordinsky, M.

AU - Khobzei, K.

AU - Lee, W. S.

AU - Malakar, S.

AU - Messenger, A.

AU - McMichael, A.

AU - Mirmirani, P.

AU - Ovcharenko, Y.

AU - Papanikou, S.

AU - Pinto, G. M.

AU - Piraccini, B. M.

AU - Pirmez, R.

AU - Reygagne, P.

AU - Roberts, J.

AU - Rudnicka, L.

AU - Saceda-Corralo, D.

AU - Shapiro, J.

AU - Silyuk, T.

AU - Sinclair, R.

AU - Soares, R. O.

AU - Souissi, A.

AU - Vogt, A.

AU - Washenik, K.

AU - Zlotogorski, A.

AU - Canfield, D.

AU - Vano-Galvan, S.

PY - 2021/12

Y1 - 2021/12

N2 - Background: Frontal fibrosing alopecia (FFA) has become one of the most common causes of cicatricial alopecia worldwide. However, there is a lack of clear aetiology and robust clinical trial evidence for the efficacy and safety of agents currently used for treatment. Objectives: To enable data to be collected worldwide on FFA using common criteria and assessment methods. Methods: A multicentre, international group of experts in hair loss was convened by email to create consensus recommendations for clinical trials. Consensus was defined at > 90% agreement on each recommended part of these guidelines. Results: Standardized diagnostic criteria, severity rating, staging, and investigator and patient assessment of scalp hair loss and other clinical features of FFA were created. Conclusions: These guidelines should allow the collection of reliable aggregate data on FFA and advance efforts in both clinical and basic research to close knowledge gaps in this condition.

AB - Background: Frontal fibrosing alopecia (FFA) has become one of the most common causes of cicatricial alopecia worldwide. However, there is a lack of clear aetiology and robust clinical trial evidence for the efficacy and safety of agents currently used for treatment. Objectives: To enable data to be collected worldwide on FFA using common criteria and assessment methods. Methods: A multicentre, international group of experts in hair loss was convened by email to create consensus recommendations for clinical trials. Consensus was defined at > 90% agreement on each recommended part of these guidelines. Results: Standardized diagnostic criteria, severity rating, staging, and investigator and patient assessment of scalp hair loss and other clinical features of FFA were created. Conclusions: These guidelines should allow the collection of reliable aggregate data on FFA and advance efforts in both clinical and basic research to close knowledge gaps in this condition.

UR - http://www.scopus.com/inward/record.url?scp=85112387463&partnerID=8YFLogxK

U2 - 10.1111/bjd.20567

DO - 10.1111/bjd.20567

M3 - Article

C2 - 34105768

AN - SCOPUS:85112387463

SN - 0007-0963

VL - 185

SP - 1221

EP - 1231

JO - British Journal of Dermatology

JF - British Journal of Dermatology

IS - 6

ER -

Guidelines for clinical trials of frontal fibrosing alopecia: consensus recommendations from the International FFA Cooperative Group (IFFACG)*

Abstract

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