Guidelines for the welfare and use of animals in cancer research

P. Workman; E. O. Aboagye; F. Balkwill; A. Balmain; G. Bruder; D. J. Chaplin; J. A. Double; J. Everitt; D. A H Farningham; M. J. Glennie; L. R. Kelland; V. Robinson; I. J. Stratford; G. M. Tozer; S. Watson; S. R. Wedge; S. A. Eccles; V. Navaratnam; S. Ryder

doi:10.1038/sj.bjc.6605642

Guidelines for the welfare and use of animals in cancer research

P. Workman, E. O. Aboagye, F. Balkwill, A. Balmain, G. Bruder, D. J. Chaplin, J. A. Double, J. Everitt, D. A H Farningham, M. J. Glennie, L. R. Kelland, V. Robinson, I. J. Stratford, G. M. Tozer, S. Watson, S. R. Wedge, S. A. Eccles, V. Navaratnam, S. Ryder

Research output: Contribution to journal › Article › peer-review

Abstract

Animal experiments remain essential to understand the fundamental mechanisms underpinning malignancy and to discover improved methods to prevent, diagnose and treat cancer. Excellent standards of animal care are fully consistent with the conduct of high quality cancer research. Here we provide updated guidelines on the welfare and use of animals in cancer research. All experiments should incorporate the 3Rs: replacement, reduction and refinement. Focusing on animal welfare, we present recommendations on all aspects of cancer research, including: study design, statistics and pilot studies; choice of tumour models (e.g., genetically engineered, orthotopic and metastatic); therapy (including drugs and radiation); imaging (covering techniques, anaesthesia and restraint); humane endpoints (including tumour burden and site); and publication of best practice. © 2010 Cancer Research UK All rights reserved.

Original language	English
Pages (from-to)	1555-1577
Number of pages	22
Journal	British Journal of Cancer
Volume	102
Issue number	11
DOIs	https://doi.org/10.1038/sj.bjc.6605642
Publication status	Published - 25 May 2010

Keywords

Animal welfare
Cancer research
Fundamental and translational research
Genetically engineered mouse models
Human tumour xenografts
Metastatic models
Orthotopic models
Pilot studies
Reduction and refinement (3Rs)
Replacement
Therapy
Tumour models

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Workman, P., Aboagye, E. O., Balkwill, F., Balmain, A., Bruder, G., Chaplin, D. J., Double, J. A., Everitt, J., Farningham, D. A. H., Glennie, M. J., Kelland, L. R., Robinson, V., Stratford, I. J., Tozer, G. M., Watson, S., Wedge, S. R., Eccles, S. A., Navaratnam, V., & Ryder, S. (2010). Guidelines for the welfare and use of animals in cancer research. British Journal of Cancer, 102(11), 1555-1577. https://doi.org/10.1038/sj.bjc.6605642

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abstract = "Animal experiments remain essential to understand the fundamental mechanisms underpinning malignancy and to discover improved methods to prevent, diagnose and treat cancer. Excellent standards of animal care are fully consistent with the conduct of high quality cancer research. Here we provide updated guidelines on the welfare and use of animals in cancer research. All experiments should incorporate the 3Rs: replacement, reduction and refinement. Focusing on animal welfare, we present recommendations on all aspects of cancer research, including: study design, statistics and pilot studies; choice of tumour models (e.g., genetically engineered, orthotopic and metastatic); therapy (including drugs and radiation); imaging (covering techniques, anaesthesia and restraint); humane endpoints (including tumour burden and site); and publication of best practice. {\textcopyright} 2010 Cancer Research UK All rights reserved.",

keywords = "Animal welfare, Cancer research, Fundamental and translational research, Genetically engineered mouse models, Human tumour xenografts, Metastatic models, Orthotopic models, Pilot studies, Reduction and refinement (3Rs), Replacement, Therapy, Tumour models",

author = "P. Workman and Aboagye, {E. O.} and F. Balkwill and A. Balmain and G. Bruder and Chaplin, {D. J.} and Double, {J. A.} and J. Everitt and Farningham, {D. A H} and Glennie, {M. J.} and Kelland, {L. R.} and V. Robinson and Stratford, {I. J.} and Tozer, {G. M.} and S. Watson and Wedge, {S. R.} and Eccles, {S. A.} and V. Navaratnam and S. Ryder",

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Workman, P, Aboagye, EO, Balkwill, F, Balmain, A, Bruder, G, Chaplin, DJ, Double, JA, Everitt, J, Farningham, DAH, Glennie, MJ, Kelland, LR, Robinson, V, Stratford, IJ, Tozer, GM, Watson, S, Wedge, SR, Eccles, SA, Navaratnam, V & Ryder, S 2010, 'Guidelines for the welfare and use of animals in cancer research', British Journal of Cancer, vol. 102, no. 11, pp. 1555-1577. https://doi.org/10.1038/sj.bjc.6605642

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AU - Workman, P.

AU - Aboagye, E. O.

AU - Balkwill, F.

AU - Balmain, A.

AU - Bruder, G.

AU - Chaplin, D. J.

AU - Double, J. A.

AU - Everitt, J.

AU - Farningham, D. A H

AU - Glennie, M. J.

AU - Kelland, L. R.

AU - Robinson, V.

AU - Stratford, I. J.

AU - Tozer, G. M.

AU - Watson, S.

AU - Wedge, S. R.

AU - Eccles, S. A.

AU - Navaratnam, V.

AU - Ryder, S.

PY - 2010/5/25

Y1 - 2010/5/25

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AB - Animal experiments remain essential to understand the fundamental mechanisms underpinning malignancy and to discover improved methods to prevent, diagnose and treat cancer. Excellent standards of animal care are fully consistent with the conduct of high quality cancer research. Here we provide updated guidelines on the welfare and use of animals in cancer research. All experiments should incorporate the 3Rs: replacement, reduction and refinement. Focusing on animal welfare, we present recommendations on all aspects of cancer research, including: study design, statistics and pilot studies; choice of tumour models (e.g., genetically engineered, orthotopic and metastatic); therapy (including drugs and radiation); imaging (covering techniques, anaesthesia and restraint); humane endpoints (including tumour burden and site); and publication of best practice. © 2010 Cancer Research UK All rights reserved.

KW - Animal welfare

KW - Cancer research

KW - Fundamental and translational research

KW - Genetically engineered mouse models

KW - Human tumour xenografts

KW - Metastatic models

KW - Orthotopic models

KW - Pilot studies

KW - Reduction and refinement (3Rs)

KW - Replacement

KW - Therapy

KW - Tumour models

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DO - 10.1038/sj.bjc.6605642

M3 - Article

C2 - 20502460

SN - 0007-0920

VL - 102

SP - 1555

EP - 1577

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 11

ER -

Guidelines for the welfare and use of animals in cancer research

Abstract

Keywords

UN SDGs

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