Gynaecological Cancer in Older Adults with Frailty

Louise Wan, Christopher Steer, Bridget Josephs, Anthea Cree

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Gynaecological cancer consists of five individual subsites: ovarian, endometrial, cervical, vaginal and vulval cancer. The proportion of older patients with frailty diagnosed with the different types of gynaecological cancer varies but in all subsites the number of these patients is increasing. Older age and frailty influence both the investigation and management of gynaecological cancers. In common with many other cancers, specific evidence to guide treatment in older patients with frailty is limited. This chapter will cover all five subsites of gynaecological cancer and provide a review of the evidence available for their management from early to advanced stages. Where this evidence is lacking, a frailty specific approach is taken, highlighting the potential benefits and limitations of standard treatments. Advances in systemic therapy, surgery and radiotherapy, which may particularly improve outcomes for patients with frailty are highlighted. The need for shared decision-making is emphasised throughout.
Original languageEnglish
Title of host publicationFrailty in Older Adults with Cancer
PublisherSpringer Nature
Number of pages20
ISBN (Print)978-3-030-89161-9
Publication statusPublished - 15 Feb 2022

Research Beacons, Institutes and Platforms

  • Manchester Cancer Research Centre


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