Haem d1: Development of a new coupling procedure leading to the synthesis of isobacteriochlorins

Richard L. Mackman; Jason Micklefield; Michael H. Block; Finian J. Leeper; Alan R. Battersby

Haem d1: Development of a new coupling procedure leading to the synthesis of isobacteriochlorins

Richard L. Mackman, Jason Micklefield, Michael H. Block, Finian J. Leeper, Alan R. Battersby

Research output: Contribution to journal › Article › peer-review

Abstract

A new approach has been developed for construction of the western and eastern lactams, e.g. 2 and 3, needed for synthesis of isobacteriochlorins. It involves acylation of pyrroles with lactonic acids to form ketones. These are then efficiently converted into the desired lactams by a short sequence of reactions. All the steps are high yielding and simple to carry out.

Original language	English
Pages (from-to)	2111-2122
Number of pages	11
Journal	Journal of the Chemical Society. Perkin Transactions 1
Issue number	14
Publication status	Published - 21 Jul 1997

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title = "Haem d1: Development of a new coupling procedure leading to the synthesis of isobacteriochlorins",

abstract = "A new approach has been developed for construction of the western and eastern lactams, e.g. 2 and 3, needed for synthesis of isobacteriochlorins. It involves acylation of pyrroles with lactonic acids to form ketones. These are then efficiently converted into the desired lactams by a short sequence of reactions. All the steps are high yielding and simple to carry out.",

author = "Mackman, {Richard L.} and Jason Micklefield and Block, {Michael H.} and Leeper, {Finian J.} and Battersby, {Alan R.}",

year = "1997",

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pages = "2111--2122",

journal = "Journal of the Chemical Society. Perkin Transactions 1",

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T1 - Haem d1: Development of a new coupling procedure leading to the synthesis of isobacteriochlorins

AU - Mackman, Richard L.

AU - Micklefield, Jason

AU - Block, Michael H.

AU - Leeper, Finian J.

AU - Battersby, Alan R.

PY - 1997/7/21

Y1 - 1997/7/21

N2 - A new approach has been developed for construction of the western and eastern lactams, e.g. 2 and 3, needed for synthesis of isobacteriochlorins. It involves acylation of pyrroles with lactonic acids to form ketones. These are then efficiently converted into the desired lactams by a short sequence of reactions. All the steps are high yielding and simple to carry out.

AB - A new approach has been developed for construction of the western and eastern lactams, e.g. 2 and 3, needed for synthesis of isobacteriochlorins. It involves acylation of pyrroles with lactonic acids to form ketones. These are then efficiently converted into the desired lactams by a short sequence of reactions. All the steps are high yielding and simple to carry out.

M3 - Article

SN - 1472-7781

SP - 2111

EP - 2122

JO - Journal of the Chemical Society. Perkin Transactions 1

JF - Journal of the Chemical Society. Perkin Transactions 1

IS - 14

ER -

Haem d1: Development of a new coupling procedure leading to the synthesis of isobacteriochlorins

Abstract

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