Haemostasis using a ready-to-use collagen sponge coated with activated thrombin and fibrinogen

Omer Aziz, Thanos Athanasiou, Ara Darzi

Research output: Contribution to journalReview articlepeer-review


Adequate haemostasis is an important part of any surgical procedure, but particularly so in the case of visceral organ surgery where apparently insignificant ooze can ultimately result in significant haemorrhage and coagulopathy. To achieve haemorrhage control, the surgeon may use conventional techniques (eg, suture ligation, diathermy, and swab compression), but failing this has the option of using physical coagulation tools (eg, the argon beam coagulator) and haemostasis adjuncts (eg, fibrin glues and collagen sheets). Advances in manufacturing have led to development of several other haemostatic products including absorbable gelatin sponges, cyanoacrylates, and polymer-based adhesives. One such product consists of a fixed, ready-to-use equine collagen sponge coated with human thrombin and fibrinogen. It may be applied directly to the bleeding surface, without the need for preparation or reconstitution. This chapter reviews the published evidence and compares its use to other classes of haemostasis adjuncts across a range of surgical specialties, namely hepatic, splenic, thoracic, vascular, and minimally invasive surgery. It also aims to highlight the apparent advantages and limitations of the fibrinogen and thrombin-coated collagen sponge compared to other commercially available haemostasis adjuncts, and identify potential applications for the product.

Original languageEnglish
Pages (from-to)35-40
Number of pages6
JournalSurgical technology international
Publication statusPublished - 2005


  • Animals
  • Aprotinin/administration & dosage
  • Blood Loss, Surgical/prevention & control
  • Collagen/administration & dosage
  • Drug Combinations
  • Fibrinogen/administration & dosage
  • Hemostasis, Surgical/instrumentation
  • Hemostatics/administration & dosage
  • Humans
  • Surgical Sponges
  • Thrombin/administration & dosage


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