HDL quality or cholesterol cargo: What really matters - Spotlight on sphingosine-1-phosphate-rich HDL

Emmanuel E. Egom, Mamas A. Mamas, Handrean Soran

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Purpose of review: The absolute level of HDL cholesterol (HDL-C) may not be the only criterion contributing to their antiatherothrombotic effects. This review focuses on evidence in support of the concept that HDL-bound sphingosine-1-phosphate (S1P) plays a role in different HDL atheroprotective properties and may represent a potential target for therapeutic interventions. Recent findings: Recent large randomized clinical trials testing the hypothesis of raising HDL-C with niacin and dalcetrapib in statin-treated patients failed to improve cardiovascular outcomes. Emerging evidence suggests that many of the cardioprotective functions of HDL, such as vasodilation, angiogenesis and endothelial barrier function, protection against ischemia/reperfusion injury, and inhibition of atherosclerosis, may be attributable to its S1P cargo. HDL-associated S1P may represent a future therapeutic target. Summary: HDL functionality is affected by its composition and there is evidence to suggest S1P plays a role in some of HDL's functions and atheroprotective properties. © 2013 Wolters Kluwer Health.
    Original languageEnglish
    Pages (from-to)351-356
    Number of pages5
    JournalCurrent opinion in lipidology
    Volume24
    Issue number4
    DOIs
    Publication statusPublished - Aug 2013

    Keywords

    • Atherothrombotic
    • Coronary artery disease
    • HDL
    • HDL functionality
    • Sphingosine-1-phosphate

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