Healing of tooth extraction sockets in the streptozotocin diabetic rat model: Induction of cartilage by BMP-6

Y. C. Shyng; C. Y. Chi; H. Devlin; P. Sloan

doi:10.3109/08977194.2010.527966

Healing of tooth extraction sockets in the streptozotocin diabetic rat model: Induction of cartilage by BMP-6

Y. C. Shyng, C. Y. Chi, H. Devlin, P. Sloan

Research output: Contribution to journal › Article › peer-review

Abstract

Cartilage does not form in the tooth extraction socket of the normal rat. The aim of the study was to determine if adding BMP-6 to the extraction socket would cause chondrogenic differentiation in the diabetic rat.A group of 8-week-old rats were injected intraperitoneally with a diabetogenic agent, streptozotocin, and a control group received citrate buffer only. Three weeks later, the maxillary molar teeth were extracted and either BMP-6 or saline applied to the extraction sockets. Rats from each group were killed on days 3, 5, 7, and 9 after tooth extraction. In the diabetic rats treated with BMP-6, there was a cellular subperiosteal reaction at day 3 in the extra-alveolar tissues, which by day 7 had formed a large mass of cartilage.Cartilage was induced in the subperiosteal region of the socket extra-alveolar bone following the application of BMP-6 in the diabetic rat. © 2010 Informa UK, Ltd.

Original language	English
Pages (from-to)	447-451
Number of pages	4
Journal	Growth Factors
Volume	28
Issue number	6
DOIs	https://doi.org/10.3109/08977194.2010.527966
Publication status	Published - Dec 2010

Keywords

BMP-6
Diabetes
Socket healing

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/08977194.2010.527966

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title = "Healing of tooth extraction sockets in the streptozotocin diabetic rat model: Induction of cartilage by BMP-6",

abstract = "Cartilage does not form in the tooth extraction socket of the normal rat. The aim of the study was to determine if adding BMP-6 to the extraction socket would cause chondrogenic differentiation in the diabetic rat.A group of 8-week-old rats were injected intraperitoneally with a diabetogenic agent, streptozotocin, and a control group received citrate buffer only. Three weeks later, the maxillary molar teeth were extracted and either BMP-6 or saline applied to the extraction sockets. Rats from each group were killed on days 3, 5, 7, and 9 after tooth extraction. In the diabetic rats treated with BMP-6, there was a cellular subperiosteal reaction at day 3 in the extra-alveolar tissues, which by day 7 had formed a large mass of cartilage.Cartilage was induced in the subperiosteal region of the socket extra-alveolar bone following the application of BMP-6 in the diabetic rat. {\textcopyright} 2010 Informa UK, Ltd.",

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AU - Shyng, Y. C.

AU - Chi, C. Y.

AU - Devlin, H.

AU - Sloan, P.

PY - 2010/12

Y1 - 2010/12

N2 - Cartilage does not form in the tooth extraction socket of the normal rat. The aim of the study was to determine if adding BMP-6 to the extraction socket would cause chondrogenic differentiation in the diabetic rat.A group of 8-week-old rats were injected intraperitoneally with a diabetogenic agent, streptozotocin, and a control group received citrate buffer only. Three weeks later, the maxillary molar teeth were extracted and either BMP-6 or saline applied to the extraction sockets. Rats from each group were killed on days 3, 5, 7, and 9 after tooth extraction. In the diabetic rats treated with BMP-6, there was a cellular subperiosteal reaction at day 3 in the extra-alveolar tissues, which by day 7 had formed a large mass of cartilage.Cartilage was induced in the subperiosteal region of the socket extra-alveolar bone following the application of BMP-6 in the diabetic rat. © 2010 Informa UK, Ltd.

AB - Cartilage does not form in the tooth extraction socket of the normal rat. The aim of the study was to determine if adding BMP-6 to the extraction socket would cause chondrogenic differentiation in the diabetic rat.A group of 8-week-old rats were injected intraperitoneally with a diabetogenic agent, streptozotocin, and a control group received citrate buffer only. Three weeks later, the maxillary molar teeth were extracted and either BMP-6 or saline applied to the extraction sockets. Rats from each group were killed on days 3, 5, 7, and 9 after tooth extraction. In the diabetic rats treated with BMP-6, there was a cellular subperiosteal reaction at day 3 in the extra-alveolar tissues, which by day 7 had formed a large mass of cartilage.Cartilage was induced in the subperiosteal region of the socket extra-alveolar bone following the application of BMP-6 in the diabetic rat. © 2010 Informa UK, Ltd.

KW - BMP-6

KW - Diabetes

KW - Socket healing

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Healing of tooth extraction sockets in the streptozotocin diabetic rat model: Induction of cartilage by BMP-6

Abstract

Keywords

UN SDGs

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