Heart failure, diastolic dysfunction and atrial fibrillation; Mechanistic insight of a complex inter-relationship

Jane Caldwell, J. C. Caldwell, M. A. Mamas

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Atrial fibrillation (AF) and heart failure (HF) commonly coexist, and their co-presence is associated with adverse outcomes relating to thromboembolic events, HF progression, hospitalisation and death. Diastolic dysfunction (DD) is also frequently present in patients with HF and is an independent predictor of hospitalisation and mortality. The presence of DD is a strong predictor of incident AF in patients with HF. In this review, we provide mechanistic insight into pathophysiological processes that frequently promote the occurrence of AF, HF and DD and outline the yin-yang relationship between AF, DD and HF. More recently, invasive studies have also shown that asymptomatic paroxysmal atrial fibrillation (PAF) is a common phenomenon in HF patients. We examine complex inter-relationships between PAF, HF and DD and speculate upon the possible clinical influence of undiagnosed PAF in HF patients. © 2010 Springer Science+Business Media, LLC.
    Original languageEnglish
    Pages (from-to)27-33
    Number of pages6
    JournalHeart Failure Reviews
    Volume17
    Issue number1
    DOIs
    Publication statusPublished - Jan 2012

    Keywords

    • Diastolic dysfunction
    • Heart failure
    • Paroxysmal atrial fibrillation

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