Heavily fluorinated carbohydrates as enzyme substrates: Oxidation of tetrafluorinated galactose by galactose oxidase

Avgousta Ioannou; Elena Cini; Roxana S. Timofte; Sabine L. Flitsch; Nicholas J. Turner; Bruno Linclau

doi:10.1039/c1cc13956h

Heavily fluorinated carbohydrates as enzyme substrates: Oxidation of tetrafluorinated galactose by galactose oxidase

Avgousta Ioannou
, Elena Cini
, Roxana S. Timofte
, Sabine L. Flitsch
, Nicholas J. Turner
, Bruno Linclau

Research output: Contribution to journal › Article › peer-review

Abstract

Galactose oxidase (GOase) was shown to oxidise several C2/C3 fluorinated galactose analogues. Interestingly, the enzyme was able to distinguish between the 2,3-tetrafluorinated galactose and its epimeric glucose analogue, and this represents the first reported biotransformation of a heavily fluorinated sugar. © 2011 The Royal Society of Chemistry.

Original language	English
Pages (from-to)	11228-11230
Number of pages	2
Journal	Chemical Communications
Volume	47
Issue number	40
DOIs	https://doi.org/10.1039/c1cc13956h
Publication status	Published - 28 Oct 2011

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title = "Heavily fluorinated carbohydrates as enzyme substrates: Oxidation of tetrafluorinated galactose by galactose oxidase",

abstract = "Galactose oxidase (GOase) was shown to oxidise several C2/C3 fluorinated galactose analogues. Interestingly, the enzyme was able to distinguish between the 2,3-tetrafluorinated galactose and its epimeric glucose analogue, and this represents the first reported biotransformation of a heavily fluorinated sugar. {\textcopyright} 2011 The Royal Society of Chemistry.",

author = "Avgousta Ioannou and Elena Cini and Timofte, \{Roxana S.\} and Flitsch, \{Sabine L.\} and Turner, \{Nicholas J.\} and Bruno Linclau",

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doi = "10.1039/c1cc13956h",

language = "English",

volume = "47",

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journal = "Chemical Communications",

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T1 - Heavily fluorinated carbohydrates as enzyme substrates: Oxidation of tetrafluorinated galactose by galactose oxidase

AU - Ioannou, Avgousta

AU - Cini, Elena

AU - Timofte, Roxana S.

AU - Flitsch, Sabine L.

AU - Turner, Nicholas J.

AU - Linclau, Bruno

PY - 2011/10/28

Y1 - 2011/10/28

N2 - Galactose oxidase (GOase) was shown to oxidise several C2/C3 fluorinated galactose analogues. Interestingly, the enzyme was able to distinguish between the 2,3-tetrafluorinated galactose and its epimeric glucose analogue, and this represents the first reported biotransformation of a heavily fluorinated sugar. © 2011 The Royal Society of Chemistry.

AB - Galactose oxidase (GOase) was shown to oxidise several C2/C3 fluorinated galactose analogues. Interestingly, the enzyme was able to distinguish between the 2,3-tetrafluorinated galactose and its epimeric glucose analogue, and this represents the first reported biotransformation of a heavily fluorinated sugar. © 2011 The Royal Society of Chemistry.

U2 - 10.1039/c1cc13956h

DO - 10.1039/c1cc13956h

M3 - Article

SN - 1359-7345

VL - 47

SP - 11228

EP - 11230

JO - Chemical Communications

JF - Chemical Communications

IS - 40

ER -

Heavily fluorinated carbohydrates as enzyme substrates: Oxidation of tetrafluorinated galactose by galactose oxidase

Abstract

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