Hedgehog signaling controls T cell killing at the immunological synapse.

la Roche M de; AT Ritter; KL Angus; C Dinsmore; CH Earnshaw; JF Reiter; GM Griffiths

doi:10.1126/science.1244689

Hedgehog signaling controls T cell killing at the immunological synapse.

la Roche M de, AT Ritter, KL Angus, C Dinsmore, CH Earnshaw, JF Reiter, GM Griffiths

Research output: Contribution to journal › Article › peer-review

Abstract

Hedgehog (Hh) signaling is best known for its role in development and is a key signaling component of primary cilia. Hh signaling plays a role in T cell development, but whether Hh signaling plays a role in the function of mature effector T cells is unclear. De la Roche et al. (p. 1247; see the Perspective by Le Borgne and Shaw) now show that T cell receptor signaling triggers Hh signaling. When Hh signaling is disrupted, centrosome polarization to the immunological synapse is reduced, and cytotoxic T cell–mediated killing is impaired.

Original language	Undefined
Journal	Science
DOIs	https://doi.org/10.1126/science.1244689
Publication status	Published - Dec 2013

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title = "Hedgehog signaling controls T cell killing at the immunological synapse.",

abstract = "Hedgehog (Hh) signaling is best known for its role in development and is a key signaling component of primary cilia. Hh signaling plays a role in T cell development, but whether Hh signaling plays a role in the function of mature effector T cells is unclear. De la Roche et al. (p. 1247; see the Perspective by Le Borgne and Shaw) now show that T cell receptor signaling triggers Hh signaling. When Hh signaling is disrupted, centrosome polarization to the immunological synapse is reduced, and cytotoxic T cell–mediated killing is impaired.",

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AU - de, la Roche M

AU - Ritter, AT

AU - Angus, KL

AU - Dinsmore, C

AU - Earnshaw, CH

AU - Reiter, JF

AU - Griffiths, GM

PY - 2013/12

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N2 - Hedgehog (Hh) signaling is best known for its role in development and is a key signaling component of primary cilia. Hh signaling plays a role in T cell development, but whether Hh signaling plays a role in the function of mature effector T cells is unclear. De la Roche et al. (p. 1247; see the Perspective by Le Borgne and Shaw) now show that T cell receptor signaling triggers Hh signaling. When Hh signaling is disrupted, centrosome polarization to the immunological synapse is reduced, and cytotoxic T cell–mediated killing is impaired.

AB - Hedgehog (Hh) signaling is best known for its role in development and is a key signaling component of primary cilia. Hh signaling plays a role in T cell development, but whether Hh signaling plays a role in the function of mature effector T cells is unclear. De la Roche et al. (p. 1247; see the Perspective by Le Borgne and Shaw) now show that T cell receptor signaling triggers Hh signaling. When Hh signaling is disrupted, centrosome polarization to the immunological synapse is reduced, and cytotoxic T cell–mediated killing is impaired.

UR - http://europepmc.org/abstract/med/24311692

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DO - 10.1126/science.1244689

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JO - Science

JF - Science

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Hedgehog signaling controls T cell killing at the immunological synapse.

Abstract

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