Helical peptaibol mimics are better ionophores when racemic than when enantiopure

S.J. Pike; J.E. Jones; J. Raftery; J. Clayden; S.J. Webb

doi:10.1039/C5OB01652E

Helical peptaibol mimics are better ionophores when racemic than when enantiopure

S.J. Pike, J.E. Jones, J. Raftery, J. Clayden, S.J. Webb

Research output: Contribution to journal › Article › peer-review

Abstract

Helical peptide foldamers rich in α-aminoisobutyric acid (Aib) act as peptaibol-mimicking ionophores in the phospholipid bilayers of artificial vesicles. Racemic samples of these foldamers are more active than their enantiopure counterparts, which was attributed to differing propensities to form aggregates with crystal-like features in the bilayer.

Original language	English
Pages (from-to)	9580-9584
Number of pages	4
Journal	Organic & biomolecular chemistry
Volume	13
Issue number	37
DOIs	https://doi.org/10.1039/C5OB01652E
Publication status	Published - 21 Aug 2015

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title = "Helical peptaibol mimics are better ionophores when racemic than when enantiopure",

abstract = "Helical peptide foldamers rich in α-aminoisobutyric acid (Aib) act as peptaibol-mimicking ionophores in the phospholipid bilayers of artificial vesicles. Racemic samples of these foldamers are more active than their enantiopure counterparts, which was attributed to differing propensities to form aggregates with crystal-like features in the bilayer.",

author = "S.J. Pike and J.E. Jones and J. Raftery and J. Clayden and S.J. Webb",

year = "2015",

month = aug,

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doi = "10.1039/C5OB01652E",

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AU - Pike, S.J.

AU - Jones, J.E.

AU - Raftery, J.

AU - Clayden, J.

AU - Webb, S.J.

PY - 2015/8/21

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AB - Helical peptide foldamers rich in α-aminoisobutyric acid (Aib) act as peptaibol-mimicking ionophores in the phospholipid bilayers of artificial vesicles. Racemic samples of these foldamers are more active than their enantiopure counterparts, which was attributed to differing propensities to form aggregates with crystal-like features in the bilayer.

U2 - 10.1039/C5OB01652E

DO - 10.1039/C5OB01652E

M3 - Article

SN - 1477-0520

VL - 13

SP - 9580

EP - 9584

JO - Organic & biomolecular chemistry

JF - Organic & biomolecular chemistry

IS - 37

ER -

Helical peptaibol mimics are better ionophores when racemic than when enantiopure

Abstract

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