Heparan sulfate proteoglycans and cancer

F. H. Blackhall; C. L R Merry; E. J. Davies; G. C. Jayson

doi:10.1054/bjoc.2001.2054

Heparan sulfate proteoglycans and cancer

F. H. Blackhall, C. L R Merry, E. J. Davies, G. C. Jayson

Research output: Contribution to journal › Article › peer-review

Abstract

Heparan sulfate proteoglycans (HSPGs) are widely distributed in mammalian tissues and involved in a number of processes related to malignancy. They are composed of a core protein to which chains of the glycosaminoglycan, heparan sulfate (HS), are attached. The existence of various classes of core protein, in addition to highly polymorphic HS chains, creates a superfamily of macromolecules with considerable diversity of structure and function. HSPGs interact with many proteins including growth factors, chemokines and structural proteins of the extracellular matrix to influence cell growth, differentiation, and the cellular response to the environment. The recent identification of two inherited syndromes that are associated with an increased cancer risk, and caused by mutations in HSPG-related genes, has intensified interest in these molecules. This review describes our current understanding of HSPGs in cancer and highlights new possibilities for therapeutic control. © 2001 Cancer Research Campaign.

Original language	English
Pages (from-to)	1094-1098
Number of pages	4
Journal	British Journal of Cancer
Volume	85
Issue number	8
DOIs	https://doi.org/10.1054/bjoc.2001.2054
Publication status	Published - 19 Oct 2001

Keywords

Cancer
Heparan sulfate
Proteoglycans

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1054/bjoc.2001.2054

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title = "Heparan sulfate proteoglycans and cancer",

abstract = "Heparan sulfate proteoglycans (HSPGs) are widely distributed in mammalian tissues and involved in a number of processes related to malignancy. They are composed of a core protein to which chains of the glycosaminoglycan, heparan sulfate (HS), are attached. The existence of various classes of core protein, in addition to highly polymorphic HS chains, creates a superfamily of macromolecules with considerable diversity of structure and function. HSPGs interact with many proteins including growth factors, chemokines and structural proteins of the extracellular matrix to influence cell growth, differentiation, and the cellular response to the environment. The recent identification of two inherited syndromes that are associated with an increased cancer risk, and caused by mutations in HSPG-related genes, has intensified interest in these molecules. This review describes our current understanding of HSPGs in cancer and highlights new possibilities for therapeutic control. {\textcopyright} 2001 Cancer Research Campaign.",

keywords = "Cancer, Heparan sulfate, Proteoglycans",

author = "Blackhall, {F. H.} and Merry, {C. L R} and Davies, {E. J.} and Jayson, {G. C.}",

year = "2001",

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doi = "10.1054/bjoc.2001.2054",

language = "English",

volume = "85",

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T1 - Heparan sulfate proteoglycans and cancer

AU - Blackhall, F. H.

AU - Merry, C. L R

AU - Davies, E. J.

AU - Jayson, G. C.

PY - 2001/10/19

Y1 - 2001/10/19

N2 - Heparan sulfate proteoglycans (HSPGs) are widely distributed in mammalian tissues and involved in a number of processes related to malignancy. They are composed of a core protein to which chains of the glycosaminoglycan, heparan sulfate (HS), are attached. The existence of various classes of core protein, in addition to highly polymorphic HS chains, creates a superfamily of macromolecules with considerable diversity of structure and function. HSPGs interact with many proteins including growth factors, chemokines and structural proteins of the extracellular matrix to influence cell growth, differentiation, and the cellular response to the environment. The recent identification of two inherited syndromes that are associated with an increased cancer risk, and caused by mutations in HSPG-related genes, has intensified interest in these molecules. This review describes our current understanding of HSPGs in cancer and highlights new possibilities for therapeutic control. © 2001 Cancer Research Campaign.

AB - Heparan sulfate proteoglycans (HSPGs) are widely distributed in mammalian tissues and involved in a number of processes related to malignancy. They are composed of a core protein to which chains of the glycosaminoglycan, heparan sulfate (HS), are attached. The existence of various classes of core protein, in addition to highly polymorphic HS chains, creates a superfamily of macromolecules with considerable diversity of structure and function. HSPGs interact with many proteins including growth factors, chemokines and structural proteins of the extracellular matrix to influence cell growth, differentiation, and the cellular response to the environment. The recent identification of two inherited syndromes that are associated with an increased cancer risk, and caused by mutations in HSPG-related genes, has intensified interest in these molecules. This review describes our current understanding of HSPGs in cancer and highlights new possibilities for therapeutic control. © 2001 Cancer Research Campaign.

KW - Cancer

KW - Heparan sulfate

KW - Proteoglycans

U2 - 10.1054/bjoc.2001.2054

DO - 10.1054/bjoc.2001.2054

M3 - Article

C2 - 11710818

SN - 0007-0920

VL - 85

SP - 1094

EP - 1098

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 8

ER -

Heparan sulfate proteoglycans and cancer

Abstract

Keywords

UN SDGs

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