Hepatocyte gp130 deficiency reduces vascular remodeling after carotid artery ligation

Gustavo Salguero; Harald Schuett; Joanna Jagielska; René Schley; Ezequiel Tallone; Maren Luchtefeld; Helmut Drexler; Werner Müller; Karsten Grote; Bernhard Schieffer

doi:10.1161/HYPERTENSIONAHA.109.136002

Hepatocyte gp130 deficiency reduces vascular remodeling after carotid artery ligation

Gustavo Salguero, Harald Schuett, Joanna Jagielska, René Schley, Ezequiel Tallone, Maren Luchtefeld, Helmut Drexler, Werner Müller, Karsten Grote, Bernhard Schieffer

Research output: Contribution to journal › Article › peer-review

Abstract

Inflammation and vascular remodeling are hallmarks of atherosclerosis, hypertension, and restenosis after angioplasty. Here we investigated the role of the hepatocyte gp130-dependent systemic acute phase response on vascular remodeling after carotid artery ligation. Mice with a hepatocyte-specific gp130 knockout on an apolipoprotein E background (gp130) were compared with control mice (gp130). Vascular remodeling was induced by permanent ligation of the left common carotid artery. This, in turn, activated the systemic acute phase reaction in gp130 mice, as measured by serum amyloid A plasma levels, which was completely abrogated in gp130 mice (P

Original language	English
Pages (from-to)	1035-1042
Number of pages	7
Journal	Hypertension
Volume	54
Issue number	5
DOIs	https://doi.org/10.1161/HYPERTENSIONAHA.109.136002
Publication status	Published - Nov 2009

Keywords

Acute phase reaction
Gp130
SMC migration/proliferation
Vascular remodeling

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1161/HYPERTENSIONAHA.109.136002

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abstract = "Inflammation and vascular remodeling are hallmarks of atherosclerosis, hypertension, and restenosis after angioplasty. Here we investigated the role of the hepatocyte gp130-dependent systemic acute phase response on vascular remodeling after carotid artery ligation. Mice with a hepatocyte-specific gp130 knockout on an apolipoprotein E background (gp130) were compared with control mice (gp130). Vascular remodeling was induced by permanent ligation of the left common carotid artery. This, in turn, activated the systemic acute phase reaction in gp130 mice, as measured by serum amyloid A plasma levels, which was completely abrogated in gp130 mice (P",

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doi = "10.1161/HYPERTENSIONAHA.109.136002",

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T1 - Hepatocyte gp130 deficiency reduces vascular remodeling after carotid artery ligation

AU - Salguero, Gustavo

AU - Schuett, Harald

AU - Jagielska, Joanna

AU - Schley, René

AU - Tallone, Ezequiel

AU - Luchtefeld, Maren

AU - Drexler, Helmut

AU - Müller, Werner

AU - Grote, Karsten

AU - Schieffer, Bernhard

PY - 2009/11

Y1 - 2009/11

N2 - Inflammation and vascular remodeling are hallmarks of atherosclerosis, hypertension, and restenosis after angioplasty. Here we investigated the role of the hepatocyte gp130-dependent systemic acute phase response on vascular remodeling after carotid artery ligation. Mice with a hepatocyte-specific gp130 knockout on an apolipoprotein E background (gp130) were compared with control mice (gp130). Vascular remodeling was induced by permanent ligation of the left common carotid artery. This, in turn, activated the systemic acute phase reaction in gp130 mice, as measured by serum amyloid A plasma levels, which was completely abrogated in gp130 mice (P

AB - Inflammation and vascular remodeling are hallmarks of atherosclerosis, hypertension, and restenosis after angioplasty. Here we investigated the role of the hepatocyte gp130-dependent systemic acute phase response on vascular remodeling after carotid artery ligation. Mice with a hepatocyte-specific gp130 knockout on an apolipoprotein E background (gp130) were compared with control mice (gp130). Vascular remodeling was induced by permanent ligation of the left common carotid artery. This, in turn, activated the systemic acute phase reaction in gp130 mice, as measured by serum amyloid A plasma levels, which was completely abrogated in gp130 mice (P

KW - Acute phase reaction

KW - Gp130

KW - SMC migration/proliferation

KW - Vascular remodeling

U2 - 10.1161/HYPERTENSIONAHA.109.136002

DO - 10.1161/HYPERTENSIONAHA.109.136002

M3 - Article

C2 - 19805641

SN - 1524-4563

VL - 54

SP - 1035

EP - 1042

JO - Hypertension

JF - Hypertension

IS - 5

ER -

Hepatocyte gp130 deficiency reduces vascular remodeling after carotid artery ligation

Abstract

Keywords

UN SDGs

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