Hepatocyte gp130 deficiency reduces vascular remodeling after carotid artery ligation

Gustavo Salguero, Harald Schuett, Joanna Jagielska, René Schley, Ezequiel Tallone, Maren Luchtefeld, Helmut Drexler, Werner Müller, Karsten Grote, Bernhard Schieffer

    Research output: Contribution to journalArticlepeer-review


    Inflammation and vascular remodeling are hallmarks of atherosclerosis, hypertension, and restenosis after angioplasty. Here we investigated the role of the hepatocyte gp130-dependent systemic acute phase response on vascular remodeling after carotid artery ligation. Mice with a hepatocyte-specific gp130 knockout on an apolipoprotein E background (gp130) were compared with control mice (gp130). Vascular remodeling was induced by permanent ligation of the left common carotid artery. This, in turn, activated the systemic acute phase reaction in gp130 mice, as measured by serum amyloid A plasma levels, which was completely abrogated in gp130 mice (P
    Original languageEnglish
    Pages (from-to)1035-1042
    Number of pages7
    Issue number5
    Publication statusPublished - Nov 2009


    • Acute phase reaction
    • Gp130
    • SMC migration/proliferation
    • Vascular remodeling


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