Heritability of chromosomal radiosensitivity in breast cancer patients: A pilot study with the lymphocyte micronucleus assay

W. Burrill; J. B P Barber; S. A. Roberts; B. Bulman; D. Scott

Heritability of chromosomal radiosensitivity in breast cancer patients: A pilot study with the lymphocyte micronucleus assay

W. Burrill, J. B P Barber, S. A. Roberts, B. Bulman, D. Scott

Research output: Contribution to journal › Article › peer-review

Abstract

Of breast cancer patients, 30% are sensitive in a lymphocyte assay of radiation-induced chromosome damage (micronucleus induction) compared with 10% of healthy controls. Twenty-two first-degree relatives of 11 sensitive patients had an average micronucleus field significantly higher than that of 68 controls. This suggests that radiosensitivity in this assay may be an inherited characteristic associated with predisposition to breast cancer.

Original language	English
Pages (from-to)	1617-1619
Number of pages	2
Journal	International Journal of Radiation Biology
Volume	76
Issue number	12
Publication status	Published - 2000

Keywords

BREAST-CANCER
CANCER
CHROMOSOMAL RADIOSENSITIVITY
DNA-REPAIR PROFICIENCY
GENES
PREDISPOSITION
radiosensitivity
RELATIVES

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Heritability of chromosomal radiosensitivity in breast cancer patients: A pilot study with the lymphocyte micronucleus assay",

abstract = "Of breast cancer patients, 30% are sensitive in a lymphocyte assay of radiation-induced chromosome damage (micronucleus induction) compared with 10% of healthy controls. Twenty-two first-degree relatives of 11 sensitive patients had an average micronucleus field significantly higher than that of 68 controls. This suggests that radiosensitivity in this assay may be an inherited characteristic associated with predisposition to breast cancer.",

keywords = "BREAST-CANCER, CANCER, CHROMOSOMAL RADIOSENSITIVITY, DNA-REPAIR PROFICIENCY, GENES, PREDISPOSITION, radiosensitivity, RELATIVES",

author = "W. Burrill and Barber, {J. B P} and Roberts, {S. A.} and B. Bulman and D. Scott",

note = "Journal1DEC383WFINT J RADIAT BIOL",

year = "2000",

language = "English",

volume = "76",

pages = "1617--1619",

journal = "International Journal of Radiation Biology",

issn = "0955-3002",

publisher = "Informa Healthcare",

number = "12",

}

TY - JOUR

T1 - Heritability of chromosomal radiosensitivity in breast cancer patients: A pilot study with the lymphocyte micronucleus assay

AU - Burrill, W.

AU - Barber, J. B P

AU - Roberts, S. A.

AU - Bulman, B.

AU - Scott, D.

N1 - Journal1DEC383WFINT J RADIAT BIOL

PY - 2000

Y1 - 2000

N2 - Of breast cancer patients, 30% are sensitive in a lymphocyte assay of radiation-induced chromosome damage (micronucleus induction) compared with 10% of healthy controls. Twenty-two first-degree relatives of 11 sensitive patients had an average micronucleus field significantly higher than that of 68 controls. This suggests that radiosensitivity in this assay may be an inherited characteristic associated with predisposition to breast cancer.

AB - Of breast cancer patients, 30% are sensitive in a lymphocyte assay of radiation-induced chromosome damage (micronucleus induction) compared with 10% of healthy controls. Twenty-two first-degree relatives of 11 sensitive patients had an average micronucleus field significantly higher than that of 68 controls. This suggests that radiosensitivity in this assay may be an inherited characteristic associated with predisposition to breast cancer.

KW - BREAST-CANCER

KW - CANCER

KW - CHROMOSOMAL RADIOSENSITIVITY

KW - DNA-REPAIR PROFICIENCY

KW - GENES

KW - PREDISPOSITION

KW - radiosensitivity

KW - RELATIVES

M3 - Article

SN - 0955-3002

VL - 76

SP - 1617

EP - 1619

JO - International Journal of Radiation Biology

JF - International Journal of Radiation Biology

IS - 12

ER -

Heritability of chromosomal radiosensitivity in breast cancer patients: A pilot study with the lymphocyte micronucleus assay

Abstract

Keywords

UN SDGs

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