TY - JOUR
T1 - Heterogeneity in head and neck cancer incidence among black populations from Africa, the Caribbean and the USA
T2 - Analysis of cancer registry data by the AC3
AU - Auguste, Aviane
AU - Gathere, Samuel
AU - Pinheiro, Paulo S
AU - Adebamowo, Clement
AU - Akintola, Adeola
AU - Alleyne-Mike, Kellie
AU - Anderson, Simon G
AU - Ashing, Kimlin
AU - Awittor, Fred Kwame
AU - Awuah, Baffour
AU - Bhakkan, Bernard
AU - Deloumeaux, Jacqueline
AU - du Plessis, Maira
AU - Ekanem, Ima-Obong A
AU - Ekanem, Uwemedimbuk
AU - Ezeome, Emmanuel
AU - Felix, Nkese
AU - Gachii, Andrew K
AU - Gaete, Stanie
AU - Gibson, Tracey
AU - Hage, Robert
AU - Harrison, Sharon
AU - Igbinoba, Festus
AU - Iseh, Kufre
AU - Kiptanui, Evans
AU - Korir, Ann
AU - Lawson-Myers, Heather-Dawn
AU - Llanos, Adana
AU - Luce, Daniele
AU - McNaughton, Dawn
AU - Odutola, Michael
AU - Omonisi, Abidemi
AU - Otu, Theresa
AU - Peruvien, Jessica
AU - Raheem, Nasiru
AU - Roach, Veronica
AU - Sobers, Natasha
AU - Uamburu, Nguundja
AU - Ragin, Camille
N1 - Funding Information:
This work was supported in part by grants R13 CA249974 , R01 CA238061 Supp , P20 CA210294 to CR and CA006927 from the National Cancer Institute , an appropriation from the Commonwealth of Pennsylvania. This project was partially supported by the TUFCCC/HC Regional Comprehensive Cancer Health Disparity Partnership , Award Number U54 CA221704 (Contact PIs: Grace X. Ma, PhD and Olorunseun O. Ogunwobi, MD, PhD). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NCI/NIH. The Guadeloupe cancer registry is supported by the French National Cancer Institute (Institut National du Cancer, INCa) and the French National Public health Agency (Santé Publique France).
Funding Information:
This work was supported in part by grants R13 CA249974, R01 CA238061 Supp, P20 CA210294 to CR and CA006927 from the National Cancer Institute, an appropriation from the Commonwealth of Pennsylvania. This project was partially supported by the TUFCCC/HC Regional Comprehensive Cancer Health Disparity Partnership, Award Number U54 CA221704 (Contact PIs: Grace X. Ma, PhD and Olorunseun O. Ogunwobi, MD, PhD). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NCI/NIH. The Guadeloupe cancer registry is supported by the French National Cancer Institute (Institut National du Cancer, INCa) and the French National Public health Agency (Santé Publique France).
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/12/1
Y1 - 2021/12/1
N2 - BACKGROUND: Africa and the Caribbean are projected to have greater increases in Head and neck cancer (HNC) burden in comparison to North America and Europe. The knowledge needed to reinforce prevention in these populations is limited. We compared for the first time, incidence rates of HNC in black populations from African, the Caribbean and USA.METHODS: Annual age-standardized incidence rates (IR) and 95% confidence intervals (95%CI) per 100,000 were calculated for 2013-2015 using population-based cancer registry data for 14,911 HNC cases from the Caribbean (Barbados, Guadeloupe, Trinidad & Tobago, N = 443), Africa (Kenya, Nigeria, N = 772) and the United States (SEER, Florida, N = 13,696). We compared rates by sub-sites and sex among countries using data from registries with high quality and completeness.RESULTS: In 2013-2015, compared to other countries, HNC incidence was highest among SEER states (IR: 18.2, 95%CI = 17.6-18.8) among men, and highest in Kenya (IR: 7.5, 95%CI = 6.3-8.7) among women. Nasopharyngeal cancer IR was higher in Kenya for men (IR: 3.1, 95%CI = 2.5-3.7) and women (IR: 1.5, 95%CI = 1.0-1.9). Female oral cavity cancer was also notably higher in Kenya (IR = 3.9, 95%CI = 3.0-4.9). Blacks from SEER states had higher incidence of laryngeal cancer (IR: 5.5, 95%CI = 5.2-5.8) compared to other countries and even Florida blacks (IR: 4.4, 95%CI = 3.9-5.0).CONCLUSION: We found heterogeneity in IRs for HNC among these diverse black populations; notably, Kenya which had distinctively higher incidence of nasopharyngeal and female oral cavity cancer. Targeted etiological investigations are warranted considering the low consumption of tobacco and alcohol among Kenyan women. Overall, our findings suggest that behavioral and environmental factors are more important determinants of HNC than race.
AB - BACKGROUND: Africa and the Caribbean are projected to have greater increases in Head and neck cancer (HNC) burden in comparison to North America and Europe. The knowledge needed to reinforce prevention in these populations is limited. We compared for the first time, incidence rates of HNC in black populations from African, the Caribbean and USA.METHODS: Annual age-standardized incidence rates (IR) and 95% confidence intervals (95%CI) per 100,000 were calculated for 2013-2015 using population-based cancer registry data for 14,911 HNC cases from the Caribbean (Barbados, Guadeloupe, Trinidad & Tobago, N = 443), Africa (Kenya, Nigeria, N = 772) and the United States (SEER, Florida, N = 13,696). We compared rates by sub-sites and sex among countries using data from registries with high quality and completeness.RESULTS: In 2013-2015, compared to other countries, HNC incidence was highest among SEER states (IR: 18.2, 95%CI = 17.6-18.8) among men, and highest in Kenya (IR: 7.5, 95%CI = 6.3-8.7) among women. Nasopharyngeal cancer IR was higher in Kenya for men (IR: 3.1, 95%CI = 2.5-3.7) and women (IR: 1.5, 95%CI = 1.0-1.9). Female oral cavity cancer was also notably higher in Kenya (IR = 3.9, 95%CI = 3.0-4.9). Blacks from SEER states had higher incidence of laryngeal cancer (IR: 5.5, 95%CI = 5.2-5.8) compared to other countries and even Florida blacks (IR: 4.4, 95%CI = 3.9-5.0).CONCLUSION: We found heterogeneity in IRs for HNC among these diverse black populations; notably, Kenya which had distinctively higher incidence of nasopharyngeal and female oral cavity cancer. Targeted etiological investigations are warranted considering the low consumption of tobacco and alcohol among Kenyan women. Overall, our findings suggest that behavioral and environmental factors are more important determinants of HNC than race.
KW - Caribbean Region/epidemiology
KW - Female
KW - Head and Neck Neoplasms/epidemiology
KW - Humans
KW - Incidence
KW - Kenya
KW - Male
KW - Nasopharyngeal Neoplasms
KW - Registries
KW - United States/epidemiology
U2 - 10.1016/j.canep.2021.102053
DO - 10.1016/j.canep.2021.102053
M3 - Article
C2 - 34743058
SN - 1877-7821
VL - 75
JO - Cancer Epidemiology
JF - Cancer Epidemiology
M1 - 102053
ER -
