Heterogeneous porous PLLA/PCL fibrous scaffold for bone tissue regeneration

Chen Meng, Dexin Tang, Xuzhao Liu, Jinmin Meng, Wenyuan Wei, Hugh Gong, Jiashen Li

Research output: Contribution to journalArticlepeer-review


Bone tissue engineering has become one of the most promising therapeutic methods to treat bone defects. A suitable scaffolding material to regenerate new bone tissues should have a high specific surface area, high porosity and a suitable surface structure which benefit cell attachment, proliferation, and differentiation. In this study, an acetone post-treatment strategy was developed to generate heterogeneous structure. After PLLA/PCL nanofibrous membranes were electrospun and collected, they were treated with acetone to generate a highly porous structure. Meanwhile, part of PCL was extracted from the fibre and enriched on the fibre surface. The cell affinity of the nanofibrous membrane was verified by human osteoblast-like cells assay. The proliferation rate of heterogeneous samples increased 190.4 %, 265.5 % and 137.9 % at day 10 compared with pristine samples. These results demonstrated that the heterogeneous PLLA/PCL nanofibrous membranes could enhance osteoblast adhesion and proliferation. With high surface area (average surface area 36.302 m2/g) and good mechanical properties (average Young's modulus 1.65 GPa and average tensile strength 5.1 MPa), the heterogeneous PLLA/PCL membrane should have potential applications in the field of bone regeneration.
Original languageEnglish
Article number123781
JournalInternational Journal of Biological Macromolecules
Early online date23 Feb 2023
Publication statusPublished - 30 Apr 2023


  • Bone tissue regeneration
  • Electrospinning
  • Hierarchical porous structure
  • Poly(L-lactic acid)
  • Polycaprolactone


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