Hidden killers: Human fungal infections

Gordon D. Brown; David W. Denning; Neil A R Gow; Stuart M. Levitz; Mihai G. Netea; Theodore C. White

doi:10.1126/scitranslmed.3004404

Hidden killers: Human fungal infections

Gordon D. Brown, David W. Denning, Neil A R Gow, Stuart M. Levitz, Mihai G. Netea, Theodore C. White

Research output: Contribution to journal › Article › peer-review

Abstract

Although fungal infections contribute substantially to human morbidity and mortality, the impact of these diseases on human health is not widely appreciated. Moreover, despite the urgent need for efficient diagnostic tests and safe and effective new drugs and vaccines, research into the pathophysiology of human fungal infections lags behind that of diseases caused by other pathogens. In this Review, we highlight the importance of fungi as human pathogens and discuss the challenges we face in combating the devastating invasive infections caused by these microorganisms, in particular in immunocompromised individuals.

Original language	English
Article number	165rv13
Journal	Science Translational Medicine
Volume	4
Issue number	165
DOIs	https://doi.org/10.1126/scitranslmed.3004404
Publication status	Published - 19 Dec 2012

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title = "Hidden killers: Human fungal infections",

abstract = "Although fungal infections contribute substantially to human morbidity and mortality, the impact of these diseases on human health is not widely appreciated. Moreover, despite the urgent need for efficient diagnostic tests and safe and effective new drugs and vaccines, research into the pathophysiology of human fungal infections lags behind that of diseases caused by other pathogens. In this Review, we highlight the importance of fungi as human pathogens and discuss the challenges we face in combating the devastating invasive infections caused by these microorganisms, in particular in immunocompromised individuals.",

author = "Brown, {Gordon D.} and Denning, {David W.} and Gow, {Neil A R} and Levitz, {Stuart M.} and Netea, {Mihai G.} and White, {Theodore C.}",

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doi = "10.1126/scitranslmed.3004404",

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AU - Denning, David W.

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AU - Levitz, Stuart M.

AU - Netea, Mihai G.

AU - White, Theodore C.

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N2 - Although fungal infections contribute substantially to human morbidity and mortality, the impact of these diseases on human health is not widely appreciated. Moreover, despite the urgent need for efficient diagnostic tests and safe and effective new drugs and vaccines, research into the pathophysiology of human fungal infections lags behind that of diseases caused by other pathogens. In this Review, we highlight the importance of fungi as human pathogens and discuss the challenges we face in combating the devastating invasive infections caused by these microorganisms, in particular in immunocompromised individuals.

AB - Although fungal infections contribute substantially to human morbidity and mortality, the impact of these diseases on human health is not widely appreciated. Moreover, despite the urgent need for efficient diagnostic tests and safe and effective new drugs and vaccines, research into the pathophysiology of human fungal infections lags behind that of diseases caused by other pathogens. In this Review, we highlight the importance of fungi as human pathogens and discuss the challenges we face in combating the devastating invasive infections caused by these microorganisms, in particular in immunocompromised individuals.

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DO - 10.1126/scitranslmed.3004404

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JO - Science Translational Medicine

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Hidden killers: Human fungal infections

Abstract

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