Hierarchical and spatial modeling and bio-additive manufacturing of multi-material constructs

N. Khani; A. Nadernezhad; Paulo Jorge Da Silva Bartolo; B. Koc

doi:10.1016/j.cirp.2017.04.132

Hierarchical and spatial modeling and bio-additive manufacturing of multi-material constructs

N. Khani, A. Nadernezhad, Paulo Jorge Da Silva Bartolo, B. Koc

Sabanci University

Research output: Contribution to journal › Article › peer-review

Abstract

In this paper, a novel method of integrated modelling and bio-additive manufacturing of hybrid bioinspired structures is presented. An algorithm is developed to generate optimized and continuous path plan while changing material and internal composition spatially and hierarchically based on the assigned functionality. Biodegradable polymers and hydrogels are used as reinforcing and biological functional bioinks respectively. A new hybrid multi-head 3D bioprinter is developed to manufacture designed three- dimensional constructs depositing bioinks layer-by-layer. Simultaneous incorporation of multiple deposition heads and integrated path planning provide the benefits of using the deposition-on-demand of multi-material bio-inks. The modelled constructs are analyzed and bioprinted

Original language	English
Pages (from-to)	229-232
Number of pages	2017
Journal	CIRP Annals - Manufacturing Technology
Volume	66
DOIs	https://doi.org/10.1016/j.cirp.2017.04.132
Publication status	Published - 3 May 2017

Keywords

Biomanufacturing
3D bioprinting
Modeling of multi-functional structures

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cirp.2017.04.132

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title = "Hierarchical and spatial modeling and bio-additive manufacturing of multi-material constructs",

abstract = "In this paper, a novel method of integrated modelling and bio-additive manufacturing of hybrid bioinspired structures is presented. An algorithm is developed to generate optimized and continuous path plan while changing material and internal composition spatially and hierarchically based on the assigned functionality. Biodegradable polymers and hydrogels are used as reinforcing and biological functional bioinks respectively. A new hybrid multi-head 3D bioprinter is developed to manufacture designed three- dimensional constructs depositing bioinks layer-by-layer. Simultaneous incorporation of multiple deposition heads and integrated path planning provide the benefits of using the deposition-on-demand of multi-material bio-inks. The modelled constructs are analyzed and bioprinted",

keywords = "Biomanufacturing, 3D bioprinting, Modeling of multi-functional structures",

author = "N. Khani and A. Nadernezhad and {Da Silva Bartolo}, {Paulo Jorge} and B. Koc",

year = "2017",

month = may,

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doi = "10.1016/j.cirp.2017.04.132",

language = "English",

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pages = "229--232",

journal = "CIRP Annals - Manufacturing Technology",

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T1 - Hierarchical and spatial modeling and bio-additive manufacturing of multi-material constructs

AU - Khani, N.

AU - Nadernezhad, A.

AU - Da Silva Bartolo, Paulo Jorge

AU - Koc, B.

PY - 2017/5/3

Y1 - 2017/5/3

N2 - In this paper, a novel method of integrated modelling and bio-additive manufacturing of hybrid bioinspired structures is presented. An algorithm is developed to generate optimized and continuous path plan while changing material and internal composition spatially and hierarchically based on the assigned functionality. Biodegradable polymers and hydrogels are used as reinforcing and biological functional bioinks respectively. A new hybrid multi-head 3D bioprinter is developed to manufacture designed three- dimensional constructs depositing bioinks layer-by-layer. Simultaneous incorporation of multiple deposition heads and integrated path planning provide the benefits of using the deposition-on-demand of multi-material bio-inks. The modelled constructs are analyzed and bioprinted

AB - In this paper, a novel method of integrated modelling and bio-additive manufacturing of hybrid bioinspired structures is presented. An algorithm is developed to generate optimized and continuous path plan while changing material and internal composition spatially and hierarchically based on the assigned functionality. Biodegradable polymers and hydrogels are used as reinforcing and biological functional bioinks respectively. A new hybrid multi-head 3D bioprinter is developed to manufacture designed three- dimensional constructs depositing bioinks layer-by-layer. Simultaneous incorporation of multiple deposition heads and integrated path planning provide the benefits of using the deposition-on-demand of multi-material bio-inks. The modelled constructs are analyzed and bioprinted

KW - Biomanufacturing

KW - 3D bioprinting

KW - Modeling of multi-functional structures

U2 - 10.1016/j.cirp.2017.04.132

DO - 10.1016/j.cirp.2017.04.132

M3 - Article

SN - 0007-8506

VL - 66

SP - 229

EP - 232

JO - CIRP Annals - Manufacturing Technology

JF - CIRP Annals - Manufacturing Technology

ER -

Hierarchical and spatial modeling and bio-additive manufacturing of multi-material constructs

Abstract

Keywords

UN SDGs

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