Hierarchical and spatial modeling and bio-additive manufacturing of multi-material constructs

N. Khani, A. Nadernezhad, Paulo Jorge Da Silva Bartolo, B. Koc

    Research output: Contribution to journalArticlepeer-review


    In this paper, a novel method of integrated modelling and bio-additive manufacturing of hybrid bioinspired structures is presented. An algorithm is developed to generate optimized and continuous path plan while changing material and internal composition spatially and hierarchically based on the assigned functionality. Biodegradable polymers and hydrogels are used as reinforcing and biological functional bioinks respectively. A new hybrid multi-head 3D bioprinter is developed to manufacture designed three- dimensional constructs depositing bioinks layer-by-layer. Simultaneous incorporation of multiple deposition heads and integrated path planning provide the benefits of using the deposition-on-demand of multi-material bio-inks. The modelled constructs are analyzed and bioprinted
    Original languageEnglish
    Pages (from-to)229-232
    Number of pages2017
    JournalCIRP Annals - Manufacturing Technology
    Publication statusPublished - 3 May 2017


    • Biomanufacturing
    • 3D bioprinting
    • Modeling of multi-functional structures


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