Hierarchical porous silk fibroin/poly(L-lactic acid) fibrous membranes towards vascular scaffolds

Jun Song, Zhongda Chen, Luis Larrea, Dexin Tang, Chen Meng, Xiangli Zhong, Tao Wang (Corresponding), Jiashen Li (Corresponding)

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Fibrous membranes played an important role to prepare tubular scaffolds for muscular artery regeneration. In this study, a strategy has been developed to combine silk fibroin (SF) with highly porous electrospun poly(L-lactic acid) (PLLA) fibrous membrane towards vascular scaffolds. After PLLA fibres were electrospun and collected, they were immersed into acetone to generate a porous structure with ultra-high surface area. While the pores on PLLA fibres were fulfilled with SF solution and dried, SF was coated uniformly and tightly on PLLA fibres. A multi-layer tubular structure of the tunica media was simulated by winding and stacking a strip of electrospun fibrous membrane. In vitro viability and morphology studies of A7r5 smooth muscle cells were undertaken for up to 14 days. Because the hydrophilicity of SF/PLLA composite fibres were improved dramatically, it had a positive effect on cell adhesion rate (97%) and proliferation (64.4%). Moreover, good cell morphology was observed via a multiphoton laser confocal microscope on SF/PLLA bioactive materials. These results demonstrated that the hierarchical porous SF/PLLA fibrous membranes are promising off-the-shelf scaffolds for muscular artery regeneration.
Original languageEnglish
Pages (from-to)1111-1120
Number of pages10
JournalInternational Journal of Biological Macromolecules
Early online date4 Nov 2020
Publication statusPublished - 4 Nov 2020


  • Electrospinning
  • Hierarchical porosity
  • Poly(L-lactic acid)
  • Silk fibroin
  • Vascular scaffold


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