High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.

Kwangwoo Kim; So-Young Bang; Hye-Soon Lee; Soo-Kyung Cho; Chan-Bum Choi; Yoon-Kyoung Sung; Tae-Hwan Kim; Jae-Bum Jun; Dae Hyun Yoo; Young Mo Kang; Seong-Kyu Kim; Chang-Hee Suh; Seung-Cheol Shim; Shin-Seok Lee; Jisoo Lee; Won Tae Chung; Jung-Yoon Choe; Hyoung Doo Shin; Jong-Young Lee; Bok-Ghee Han; Swapan K Nath; Steve Eyre; John Bowes; Dimitrios A Pappas; Joel M Kremer; Miguel A Gonzalez-Gay; Luis Rodriguez-Rodriguez; Lisbeth Arlestig; Yukinori Okada; Dorothée Diogo; Katherine P Liao; Elizabeth W Karlson; Soumya Raychaudhuri; Solbritt Rantapää-Dahlqvist; Javier Martin; Lars Klareskog; Leonid Padyukov; Peter K Gregersen; Jane Worthington; Jeffrey D Greenberg; Robert M Plenge; Sang-Cheol Bae

doi:10.1136/annrheumdis-2013-204749

High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.

Kwangwoo Kim, So-Young Bang, Hye-Soon Lee, Soo-Kyung Cho, Chan-Bum Choi, Yoon-Kyoung Sung, Tae-Hwan Kim, Jae-Bum Jun, Dae Hyun Yoo, Young Mo Kang, Seong-Kyu Kim, Chang-Hee Suh, Seung-Cheol Shim, Shin-Seok Lee, Jisoo Lee, Won Tae Chung, Jung-Yoon Choe, Hyoung Doo Shin, Jong-Young Lee, Bok-Ghee HanSwapan K Nath, Steve Eyre, John Bowes, Dimitrios A Pappas, Joel M Kremer, Miguel A Gonzalez-Gay, Luis Rodriguez-Rodriguez, Lisbeth Arlestig, Yukinori Okada, Dorothée Diogo, Katherine P Liao, Elizabeth W Karlson, Soumya Raychaudhuri, Solbritt Rantapää-Dahlqvist, Javier Martin, Lars Klareskog, Leonid Padyukov, Peter K Gregersen, Jane Worthington, Jeffrey D Greenberg, Robert M Plenge, Sang-Cheol Bae

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: A highly polygenic aetiology and high degree of allele-sharing between ancestries have been well elucidated in genetic studies of rheumatoid arthritis. Recently, the high-density genotyping array Immunochip for immune disease loci identified 14 new rheumatoid arthritis risk loci among individuals of European ancestry. Here, we aimed to identify new rheumatoid arthritis risk loci using Korean-specific Immunochip data. METHODS: We analysed Korean rheumatoid arthritis case-control samples using the Immunochip and genome-wide association studies (GWAS) array to search for new risk alleles of rheumatoid arthritis with anticitrullinated peptide antibodies. To increase power, we performed a meta-analysis of Korean data with previously published European Immunochip and GWAS data for a total sample size of 9299 Korean and 45 790 European case-control samples. RESULTS: We identified eight new rheumatoid arthritis susceptibility loci (TNFSF4, LBH, EOMES, ETS1-FLI1, COG6, RAD51B, UBASH3A and SYNGR1) that passed a genome-wide significance threshold (p

Original language	English
Pages (from-to)	e13
Journal	Annals of the rheumatic diseases
Volume	74
DOIs	https://doi.org/10.1136/annrheumdis-2013-204749
Publication status	Published - 2015

Keywords

Ant-CCP
Gene Polymorphism
Rheumatoid Arthritis

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10.1136/annrheumdis-2013-204749

Arthritis Research UK Centre of Excellence in the Genetics of Rheumatic Diseases.
Worthington, J., Barton, A., Black, G., Crow, Y., Eyre, S., Raychaudhuri, S. & Thomson, W.
1/08/13 → 31/07/18
Project: Research

Cite this

Kim, K., Bang, S-Y., Lee, H-S., Cho, S-K., Choi, C-B., Sung, Y-K., Kim, T-H., Jun, J-B., Yoo, D. H., Kang, Y. M., Kim, S-K., Suh, C-H., Shim, S-C., Lee, S-S., Lee, J., Chung, W. T., Choe, J-Y., Shin, H. D., Lee, J-Y., ... Bae, S-C. (2015). High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci. Annals of the rheumatic diseases, 74, e13. https://doi.org/10.1136/annrheumdis-2013-204749

@article{ef306f0d2ac74209a48285b15f6040f1,

title = "High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.",

abstract = "OBJECTIVE: A highly polygenic aetiology and high degree of allele-sharing between ancestries have been well elucidated in genetic studies of rheumatoid arthritis. Recently, the high-density genotyping array Immunochip for immune disease loci identified 14 new rheumatoid arthritis risk loci among individuals of European ancestry. Here, we aimed to identify new rheumatoid arthritis risk loci using Korean-specific Immunochip data. METHODS: We analysed Korean rheumatoid arthritis case-control samples using the Immunochip and genome-wide association studies (GWAS) array to search for new risk alleles of rheumatoid arthritis with anticitrullinated peptide antibodies. To increase power, we performed a meta-analysis of Korean data with previously published European Immunochip and GWAS data for a total sample size of 9299 Korean and 45 790 European case-control samples. RESULTS: We identified eight new rheumatoid arthritis susceptibility loci (TNFSF4, LBH, EOMES, ETS1-FLI1, COG6, RAD51B, UBASH3A and SYNGR1) that passed a genome-wide significance threshold (p",

keywords = "Ant-CCP, Gene Polymorphism, Rheumatoid Arthritis",

author = "Kwangwoo Kim and So-Young Bang and Hye-Soon Lee and Soo-Kyung Cho and Chan-Bum Choi and Yoon-Kyoung Sung and Tae-Hwan Kim and Jae-Bum Jun and Yoo, {Dae Hyun} and Kang, {Young Mo} and Seong-Kyu Kim and Chang-Hee Suh and Seung-Cheol Shim and Shin-Seok Lee and Jisoo Lee and Chung, {Won Tae} and Jung-Yoon Choe and Shin, {Hyoung Doo} and Jong-Young Lee and Bok-Ghee Han and Nath, {Swapan K} and Steve Eyre and John Bowes and Pappas, {Dimitrios A} and Kremer, {Joel M} and Gonzalez-Gay, {Miguel A} and Luis Rodriguez-Rodriguez and Lisbeth Arlestig and Yukinori Okada and Doroth{\'e}e Diogo and Liao, {Katherine P} and Karlson, {Elizabeth W} and Soumya Raychaudhuri and Solbritt Rantap{\"a}{\"a}-Dahlqvist and Javier Martin and Lars Klareskog and Leonid Padyukov and Gregersen, {Peter K} and Jane Worthington and Greenberg, {Jeffrey D} and Plenge, {Robert M} and Sang-Cheol Bae",

year = "2015",

doi = "10.1136/annrheumdis-2013-204749",

language = "English",

volume = "74",

pages = "e13",

journal = "Annals of the rheumatic diseases",

issn = "0003-4967",

publisher = "BMJ ",

}

Kim, K, Bang, S-Y, Lee, H-S, Cho, S-K, Choi, C-B, Sung, Y-K, Kim, T-H, Jun, J-B, Yoo, DH, Kang, YM, Kim, S-K, Suh, C-H, Shim, S-C, Lee, S-S, Lee, J, Chung, WT, Choe, J-Y, Shin, HD, Lee, J-Y, Han, B-G, Nath, SK, Eyre, S , Bowes, J, Pappas, DA, Kremer, JM, Gonzalez-Gay, MA, Rodriguez-Rodriguez, L, Arlestig, L, Okada, Y, Diogo, D, Liao, KP, Karlson, EW, Raychaudhuri, S, Rantapää-Dahlqvist, S, Martin, J, Klareskog, L, Padyukov, L, Gregersen, PK, Worthington, J, Greenberg, JD, Plenge, RM & Bae, S-C 2015, 'High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.', Annals of the rheumatic diseases, vol. 74, pp. e13. https://doi.org/10.1136/annrheumdis-2013-204749

TY - JOUR

T1 - High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.

AU - Kim, Kwangwoo

AU - Bang, So-Young

AU - Lee, Hye-Soon

AU - Cho, Soo-Kyung

AU - Choi, Chan-Bum

AU - Sung, Yoon-Kyoung

AU - Kim, Tae-Hwan

AU - Jun, Jae-Bum

AU - Yoo, Dae Hyun

AU - Kang, Young Mo

AU - Kim, Seong-Kyu

AU - Suh, Chang-Hee

AU - Shim, Seung-Cheol

AU - Lee, Shin-Seok

AU - Lee, Jisoo

AU - Chung, Won Tae

AU - Choe, Jung-Yoon

AU - Shin, Hyoung Doo

AU - Lee, Jong-Young

AU - Han, Bok-Ghee

AU - Nath, Swapan K

AU - Eyre, Steve

AU - Bowes, John

AU - Pappas, Dimitrios A

AU - Kremer, Joel M

AU - Gonzalez-Gay, Miguel A

AU - Rodriguez-Rodriguez, Luis

AU - Arlestig, Lisbeth

AU - Okada, Yukinori

AU - Diogo, Dorothée

AU - Liao, Katherine P

AU - Karlson, Elizabeth W

AU - Raychaudhuri, Soumya

AU - Rantapää-Dahlqvist, Solbritt

AU - Martin, Javier

AU - Klareskog, Lars

AU - Padyukov, Leonid

AU - Gregersen, Peter K

AU - Worthington, Jane

AU - Greenberg, Jeffrey D

AU - Plenge, Robert M

AU - Bae, Sang-Cheol

PY - 2015

Y1 - 2015

N2 - OBJECTIVE: A highly polygenic aetiology and high degree of allele-sharing between ancestries have been well elucidated in genetic studies of rheumatoid arthritis. Recently, the high-density genotyping array Immunochip for immune disease loci identified 14 new rheumatoid arthritis risk loci among individuals of European ancestry. Here, we aimed to identify new rheumatoid arthritis risk loci using Korean-specific Immunochip data. METHODS: We analysed Korean rheumatoid arthritis case-control samples using the Immunochip and genome-wide association studies (GWAS) array to search for new risk alleles of rheumatoid arthritis with anticitrullinated peptide antibodies. To increase power, we performed a meta-analysis of Korean data with previously published European Immunochip and GWAS data for a total sample size of 9299 Korean and 45 790 European case-control samples. RESULTS: We identified eight new rheumatoid arthritis susceptibility loci (TNFSF4, LBH, EOMES, ETS1-FLI1, COG6, RAD51B, UBASH3A and SYNGR1) that passed a genome-wide significance threshold (p

AB - OBJECTIVE: A highly polygenic aetiology and high degree of allele-sharing between ancestries have been well elucidated in genetic studies of rheumatoid arthritis. Recently, the high-density genotyping array Immunochip for immune disease loci identified 14 new rheumatoid arthritis risk loci among individuals of European ancestry. Here, we aimed to identify new rheumatoid arthritis risk loci using Korean-specific Immunochip data. METHODS: We analysed Korean rheumatoid arthritis case-control samples using the Immunochip and genome-wide association studies (GWAS) array to search for new risk alleles of rheumatoid arthritis with anticitrullinated peptide antibodies. To increase power, we performed a meta-analysis of Korean data with previously published European Immunochip and GWAS data for a total sample size of 9299 Korean and 45 790 European case-control samples. RESULTS: We identified eight new rheumatoid arthritis susceptibility loci (TNFSF4, LBH, EOMES, ETS1-FLI1, COG6, RAD51B, UBASH3A and SYNGR1) that passed a genome-wide significance threshold (p

KW - Ant-CCP

KW - Gene Polymorphism

KW - Rheumatoid Arthritis

U2 - 10.1136/annrheumdis-2013-204749

DO - 10.1136/annrheumdis-2013-204749

M3 - Article

C2 - 24532676

VL - 74

SP - e13

JO - Annals of the rheumatic diseases

JF - Annals of the rheumatic diseases

SN - 0003-4967

ER -

High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.

Abstract

Keywords

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Projects

Arthritis Research UK Centre of Excellence in the Genetics of Rheumatic Diseases.

Cite this