High dose rate brachytherapy for prostate cancer: Standard of care and future direction

N Thiruthaneeswaran, P J Hoskin

Research output: Contribution to journalReview articlepeer-review

Abstract

High dose rate brachytherapy is a highly conformal method of radiation dose escalation for prostate cancer and one of several treatment options for men with localised disease. The large doses per fraction exploit the low alpha/beta ratio of prostate cancer cells so that biological radiation dose delivered is substantially greater than that achieved with conventional external beam delivery. This review article presents contemporary data on the rationale for high dose rate brachytherapy including treatment technique and future directions.

Original languageEnglish
Pages (from-to)66-72
Number of pages7
JournalCancer radiotherapie
Volume20
Issue number1
DOIs
Publication statusPublished - Feb 2016

Keywords

  • Androgen Antagonists/therapeutic use
  • Brachytherapy
  • Humans
  • Male
  • Patient Selection
  • Prostatic Neoplasms/radiotherapy
  • Radiotherapy Dosage
  • Radiotherapy, Image-Guided
  • Salvage Therapy

Research Beacons, Institutes and Platforms

  • Manchester Cancer Research Centre

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