High dose rate brachytherapy for prostate cancer: Standard of care and future direction

N Thiruthaneeswaran; P J Hoskin

doi:10.1016/j.canrad.2016.01.001

High dose rate brachytherapy for prostate cancer: Standard of care and future direction

N Thiruthaneeswaran, P J Hoskin

Division of Cancer Sciences (L5)

Mount Vernon Hospital

Research output: Contribution to journal › Review article › peer-review

Abstract

High dose rate brachytherapy is a highly conformal method of radiation dose escalation for prostate cancer and one of several treatment options for men with localised disease. The large doses per fraction exploit the low alpha/beta ratio of prostate cancer cells so that biological radiation dose delivered is substantially greater than that achieved with conventional external beam delivery. This review article presents contemporary data on the rationale for high dose rate brachytherapy including treatment technique and future directions.

Original language	English
Pages (from-to)	66-72
Number of pages	7
Journal	Cancer radiotherapie
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/j.canrad.2016.01.001
Publication status	Published - Feb 2016

Keywords

Androgen Antagonists/therapeutic use
Brachytherapy
Humans
Male
Patient Selection
Prostatic Neoplasms/radiotherapy
Radiotherapy Dosage
Radiotherapy, Image-Guided
Salvage Therapy

Research Beacons, Institutes and Platforms

Manchester Cancer Research Centre

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canrad.2016.01.001

Cite this

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title = "High dose rate brachytherapy for prostate cancer: Standard of care and future direction",

abstract = "High dose rate brachytherapy is a highly conformal method of radiation dose escalation for prostate cancer and one of several treatment options for men with localised disease. The large doses per fraction exploit the low alpha/beta ratio of prostate cancer cells so that biological radiation dose delivered is substantially greater than that achieved with conventional external beam delivery. This review article presents contemporary data on the rationale for high dose rate brachytherapy including treatment technique and future directions. ",

keywords = "Androgen Antagonists/therapeutic use, Brachytherapy, Humans, Male, Patient Selection, Prostatic Neoplasms/radiotherapy, Radiotherapy Dosage, Radiotherapy, Image-Guided, Salvage Therapy",

author = "N Thiruthaneeswaran and Hoskin, {P J}",

year = "2016",

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doi = "10.1016/j.canrad.2016.01.001",

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T2 - Standard of care and future direction

AU - Thiruthaneeswaran, N

AU - Hoskin, P J

PY - 2016/2

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N2 - High dose rate brachytherapy is a highly conformal method of radiation dose escalation for prostate cancer and one of several treatment options for men with localised disease. The large doses per fraction exploit the low alpha/beta ratio of prostate cancer cells so that biological radiation dose delivered is substantially greater than that achieved with conventional external beam delivery. This review article presents contemporary data on the rationale for high dose rate brachytherapy including treatment technique and future directions.

AB - High dose rate brachytherapy is a highly conformal method of radiation dose escalation for prostate cancer and one of several treatment options for men with localised disease. The large doses per fraction exploit the low alpha/beta ratio of prostate cancer cells so that biological radiation dose delivered is substantially greater than that achieved with conventional external beam delivery. This review article presents contemporary data on the rationale for high dose rate brachytherapy including treatment technique and future directions.

KW - Androgen Antagonists/therapeutic use

KW - Brachytherapy

KW - Humans

KW - Male

KW - Patient Selection

KW - Prostatic Neoplasms/radiotherapy

KW - Radiotherapy Dosage

KW - Radiotherapy, Image-Guided

KW - Salvage Therapy

U2 - 10.1016/j.canrad.2016.01.001

DO - 10.1016/j.canrad.2016.01.001

M3 - Review article

C2 - 26811209

VL - 20

SP - 66

EP - 72

JO - Cancer radiotherapie

JF - Cancer radiotherapie

SN - 1278-3218

IS - 1

ER -

High dose rate brachytherapy for prostate cancer: Standard of care and future direction

Abstract

Keywords

Research Beacons, Institutes and Platforms

UN SDGs

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