High-Field Solid-State NMR with Dynamic Nuclear Polarization

Daniel Lee; Sabine Hediger; Gael de  Paepe

doi:10.1007/978-3-319-28275-6_73-1

High-Field Solid-State NMR with Dynamic Nuclear Polarization

Daniel Lee, Sabine Hediger, Gael de Paepe

CE - Academic & Research

Research output: Chapter in Book/Conference proceeding › Chapter › peer-review

Abstract

Microwave-induced dynamic nuclear polarization (DNP) can produce hyperpolarization of nuclear spins, leading to substantial signal enhancement in NMR. This chapter discusses the contemporary application of DNP for solid-state NMR spectroscopy at high magnetic fields. The main mechanisms and polarizing agents that enable this hyperpolarization are presented, along with more practical aspects such as the effect of decreasing sample temperature and analyzing the absolute sensitivity gain from these experiments. Examples of the exploitation of DNP for studies of biomolecules, biominerals, pharmaceuticals, self-assembled organic nanostructures, and mesoporous materials are given as is an outlook as to the future of this powerful technique

Original language	English
Title of host publication	Modern Magnetic Resonance
Editors	Graham A Webb
Pages	1-17
Number of pages	17
DOIs	https://doi.org/10.1007/978-3-319-28275-6_73-1
Publication status	Published - 2017

Keywords

Dynamic nuclear polarization
Solid-state NMR
Magnetic field
Hyperpolarization
Magic angle spinning
Signal enhancement
Polarizing agent
Absolute sensitivity
Microwave
Biomolecules
Materials

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10.1007/978-3-319-28275-6_73-1

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abstract = "Microwave-induced dynamic nuclear polarization (DNP) can produce hyperpolarization of nuclear spins, leading to substantial signal enhancement in NMR. This chapter discusses the contemporary application of DNP for solid-state NMR spectroscopy at high magnetic fields. The main mechanisms and polarizing agents that enable this hyperpolarization are presented, along with more practical aspects such as the effect of decreasing sample temperature and analyzing the absolute sensitivity gain from these experiments. Examples of the exploitation of DNP for studies of biomolecules, biominerals, pharmaceuticals, self-assembled organic nanostructures, and mesoporous materials are given as is an outlook as to the future of this powerful technique",

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AU - Hediger, Sabine

AU - Paepe, Gael de

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N2 - Microwave-induced dynamic nuclear polarization (DNP) can produce hyperpolarization of nuclear spins, leading to substantial signal enhancement in NMR. This chapter discusses the contemporary application of DNP for solid-state NMR spectroscopy at high magnetic fields. The main mechanisms and polarizing agents that enable this hyperpolarization are presented, along with more practical aspects such as the effect of decreasing sample temperature and analyzing the absolute sensitivity gain from these experiments. Examples of the exploitation of DNP for studies of biomolecules, biominerals, pharmaceuticals, self-assembled organic nanostructures, and mesoporous materials are given as is an outlook as to the future of this powerful technique

AB - Microwave-induced dynamic nuclear polarization (DNP) can produce hyperpolarization of nuclear spins, leading to substantial signal enhancement in NMR. This chapter discusses the contemporary application of DNP for solid-state NMR spectroscopy at high magnetic fields. The main mechanisms and polarizing agents that enable this hyperpolarization are presented, along with more practical aspects such as the effect of decreasing sample temperature and analyzing the absolute sensitivity gain from these experiments. Examples of the exploitation of DNP for studies of biomolecules, biominerals, pharmaceuticals, self-assembled organic nanostructures, and mesoporous materials are given as is an outlook as to the future of this powerful technique

KW - Dynamic nuclear polarization

KW - Solid-state NMR

KW - Magnetic field

KW - Hyperpolarization

KW - Magic angle spinning

KW - Signal enhancement

KW - Polarizing agent

KW - Absolute sensitivity

KW - Microwave

KW - Biomolecules

KW - Materials

UR - http://dx.doi.org/10.1007/978-3-319-28275-6_73-1

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DO - 10.1007/978-3-319-28275-6_73-1

M3 - Chapter

SN - 9783319282756

SP - 1

EP - 17

BT - Modern Magnetic Resonance

A2 - Webb, Graham A

ER -

High-Field Solid-State NMR with Dynamic Nuclear Polarization

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Keywords

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