High-Grade Glioma is not a Feature of Neurofibromatosis Type 2 in the Unirradiated Patient.

Andrew King; Rutherford SA; Hammerbeck-Ward C; Lloyd SK; Freeman SM; Pathmanaban ON; Rodriguez-Valero M; Thomas OM; Laitt RD; Stivaros S; Kellett M; Evans DG

doi:10.1093/neuros/nyx374

High-Grade Glioma is not a Feature of Neurofibromatosis Type 2 in the Unirradiated Patient.

Andrew King
, Rutherford SA
, Hammerbeck-Ward C
, Lloyd SK
, Freeman SM
, Pathmanaban ON
, Rodriguez-Valero M
, Thomas OM
, Laitt RD
, Stivaros S
, Kellett M
, Evans DG

Research output: Contribution to journal › Article › peer-review

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Abstract

Background
The Manchester criteria for Neurofibromatosis Type 2 (NF2) includes a range of tumours, and gliomas were incorporated in the original description. The gliomas are now widely accepted to be predominantly spinal cord ependymomas.
Object
We have reviewed our database to determine whether these gliomas includes any cases of malignant glioma (WHO grade III and IV).
Methods
The prospective database consists of 1253 patients with NF2. 1009 are known to be alive at last follow up.
Results
There was a single case of glioblastoma multiforme (GBM; WHO grade IV) in the series and no WHO grade III gliomas The GBM was in a patient who had previously undergone stereotactic radiosurgery for a vestibular schwannoma.
Conclusions
High grade gliomas are not a feature of NF2 in the unirradiated patient and should be excluded from the diagnostic criteria.

Original language	Undefined
Journal	Neurosurgery
Early online date	21 Jul 2017
DOIs	https://doi.org/10.1093/neuros/nyx374
Publication status	Published - 1 Aug 2018

Keywords

Neurofibromatosis Type 2
Manchester criteria
Glioblastoma
high grade glioma
malignant glioma

Access to Document

10.1093/neuros/nyx374

NF2 and GBM Manuscript resubmissionfinalAccepted author manuscript, 56.7 KB

Cite this

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title = "High-Grade Glioma is not a Feature of Neurofibromatosis Type 2 in the Unirradiated Patient.",

abstract = "Background The Manchester criteria for Neurofibromatosis Type 2 (NF2) includes a range of tumours, and gliomas were incorporated in the original description. The gliomas are now widely accepted to be predominantly spinal cord ependymomas. Object We have reviewed our database to determine whether these gliomas includes any cases of malignant glioma (WHO grade III and IV). Methods The prospective database consists of 1253 patients with NF2. 1009 are known to be alive at last follow up. Results There was a single case of glioblastoma multiforme (GBM; WHO grade IV) in the series and no WHO grade III gliomas The GBM was in a patient who had previously undergone stereotactic radiosurgery for a vestibular schwannoma. Conclusions High grade gliomas are not a feature of NF2 in the unirradiated patient and should be excluded from the diagnostic criteria. ",

keywords = "Neurofibromatosis Type 2, Manchester criteria, Glioblastoma, high grade glioma, malignant glioma",

author = "Andrew King and Rutherford SA and Hammerbeck-Ward C and Lloyd SK and Freeman SM and Pathmanaban ON and Rodriguez-Valero M and Thomas OM and Laitt RD and Stivaros S and Kellett M and Evans DG",

year = "2018",

month = aug,

day = "1",

doi = "10.1093/neuros/nyx374",

language = "Undefined",

journal = "Neurosurgery",

issn = "1524-4040",

publisher = "Lippincott Williams \& Wilkins",

}

TY - JOUR

T1 - High-Grade Glioma is not a Feature of Neurofibromatosis Type 2 in the Unirradiated Patient.

AU - King, Andrew

AU - SA, Rutherford

AU - C, Hammerbeck-Ward

AU - SK, Lloyd

AU - SM, Freeman

AU - ON, Pathmanaban

AU - M, Rodriguez-Valero

AU - OM, Thomas

AU - RD, Laitt

AU - S, Stivaros

AU - M, Kellett

AU - DG, Evans

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Background The Manchester criteria for Neurofibromatosis Type 2 (NF2) includes a range of tumours, and gliomas were incorporated in the original description. The gliomas are now widely accepted to be predominantly spinal cord ependymomas. Object We have reviewed our database to determine whether these gliomas includes any cases of malignant glioma (WHO grade III and IV). Methods The prospective database consists of 1253 patients with NF2. 1009 are known to be alive at last follow up. Results There was a single case of glioblastoma multiforme (GBM; WHO grade IV) in the series and no WHO grade III gliomas The GBM was in a patient who had previously undergone stereotactic radiosurgery for a vestibular schwannoma. Conclusions High grade gliomas are not a feature of NF2 in the unirradiated patient and should be excluded from the diagnostic criteria.

AB - Background The Manchester criteria for Neurofibromatosis Type 2 (NF2) includes a range of tumours, and gliomas were incorporated in the original description. The gliomas are now widely accepted to be predominantly spinal cord ependymomas. Object We have reviewed our database to determine whether these gliomas includes any cases of malignant glioma (WHO grade III and IV). Methods The prospective database consists of 1253 patients with NF2. 1009 are known to be alive at last follow up. Results There was a single case of glioblastoma multiforme (GBM; WHO grade IV) in the series and no WHO grade III gliomas The GBM was in a patient who had previously undergone stereotactic radiosurgery for a vestibular schwannoma. Conclusions High grade gliomas are not a feature of NF2 in the unirradiated patient and should be excluded from the diagnostic criteria.

KW - Neurofibromatosis Type 2

KW - Manchester criteria

KW - Glioblastoma

KW - high grade glioma

KW - malignant glioma

U2 - 10.1093/neuros/nyx374

DO - 10.1093/neuros/nyx374

M3 - Article

SN - 1524-4040

JO - Neurosurgery

JF - Neurosurgery

ER -