High-level expression of cyp51B in azole-resistant clinical aspergillus fumigatus isolates

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    Objectives: Resistance to azole antifungal drugs in Aspergillus fumigatus that is not mediated by target gene mutations is now common in some locations. The aim of this study was to investigate possible new mechanisms of resistance in non-target resistance. Methods: Twelve azole-resistant A. fumigatus isolates previously shown not to carry mutations in cyp51A were tested to determine whether the alternative cyp51B gene was overexpressed. Results: Of 12 isolates one showed overinduction of cyp51B after exposure to itraconazole and another showed high constitutive expression of cyp51B. Conclusions: cyp51B overexpression is a possible azole resistance mechanism in A. fumigatus. © The Author 2012. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.
    Original languageEnglish
    Pages (from-to)512-514
    Number of pages2
    JournalJournal of Antimicrobial Chemotherapy
    Issue number3
    Publication statusPublished - Mar 2013


    • Antifungal
    • Drug resistance
    • Fungi


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