High Serum Concentrations of Aflatoxin in Nepal as Measured by Enzyme-Linked Immunosorbent Serum Assay

D. W. Denning, J. A. Sykes, A. P. Wilkinson, M. R.A. Morgan

Research output: Contribution to journalArticlepeer-review

Abstract

1 Sera from 28 Nepalis, both patients and workers in a hospital in Banepa, Nepal were examined for AFB1 by enzyme-linked immunosorbent assay (ELISA). 2 This assay, previously validated using spiked sera, provides a sensitive rapid determination of serum aflatoxin (B1, G1 and Q1). 3 All 28 sera were positive with concentrations from 60 pg ml-1 to 10 ng ml-1. 4 These results suggest that consumption of aflatoxin in Nepal is high (> 50-800 ng kg −1 d-1). 5 No reports of the degree of contamination of food, human consumption or body fluid concentrations of aflatoxin in Nepal have been previously published. 6 Aflatoxin may contribute to the development of hepatocellular carcinoma, which is probably a common tumour in Nepal.

Original languageEnglish
Pages (from-to)143-146
Number of pages4
JournalHuman & Experimental Toxicology
Volume9
Issue number3
DOIs
Publication statusPublished - May 1990

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