Highly consistent genetic alterations in childhood adrenocortical tumours detected by comparative genomic hybridization

L. A. James, A. M. Kelsey, J. M. Birch, J. M. Varley

    Research output: Contribution to journalArticlepeer-review

    Abstract

    We have examined 11 cases of childhood adrenocortical tumours for copy number changes using comparative genomic hybridization (CGH). The changes seen are highly consistent between cases, and are independent of tumour type (carcinoma versus adenoma) or the presence of a germline TP53 mutation. The regions of chromosomal gain and loss identified in this study indicate the location of genes that are potentially important in the development and progression of childhood adrenocortical tumours. Finally, the copy number changes identified in childhood tumours are distinctly different to those seen in adult cases, and we propose that this indicates that childhood tumours are of embryonal origin.
    Original languageEnglish
    Pages (from-to)300-304
    Number of pages4
    JournalBritish Journal of Cancer
    Volume81
    Issue number2
    DOIs
    Publication statusPublished - 1999

    Keywords

    • Adrenocortical tumours
    • CGH
    • Paediatric cancer

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