Highly significant linkage to chromosome 3q13.31 for rhinitis and related allergic diseases.

C. Brasch-Andersen, A. Haagerup, A. D. Børglum, J. Vestbo, T. A. Kruse

    Research output: Contribution to journalArticlepeer-review


    BACKGROUND: Allergic diseases such as asthma and rhinitis have closely related phenotypes and often occur with atopy. They show strong familial and intra-individual clustering, suggesting overlapping disease aetiology. Various loci and candidate genes have been suggested to underlie allergy. Many or all are still inconclusive. Following genome-wide scans on multiple phenotypes, we previously suggested that chromosome 3q13.12-q21.2 harbours an allergy locus. OBJECTIVE: To identify candidate loci in the Danish population, two additional independent sets of sib-pair families were fine-scale mapped in candidate regions showing maximum likelihood scores (MLS) > or =1.5 in the genome-wide scans. RESULTS: Twenty eight microsatellite markers in a denser map on chromosome 3q were analysed in 236 allergy sib-pair families including 125 sib pairs with rhinitis. We report significant evidence for linkage to chromosome 3q13.31 for rhinitis (MLS 5.55, identity by descent (IBD) 63.9%) and atopy (increased specific immunoglobulin E) (MLS 3.71, IBD 61.7%). We obtained an MLS of 5.1 (IBD 67.3%) at 3q13.31 when sib pairs with both rhinitis and atopy were analysed. CONCLUSION: This study reports the first statistically significant evidence for a genetic susceptibility locus for rhinitis and to our knowledge shows the most significant evidence to date of linkage for any allergy phenotype.
    Original languageEnglish
    Pages (from-to)e10
    JournalJournal of Medical Genetics
    Issue number3
    Publication statusPublished - Mar 2006


    • genetics: Asthma
    • Chromosome Mapping
    • Chromosomes, Human, Pair 3
    • blood: DNA
    • Denmark
    • Genetic Markers
    • Genotype
    • Humans
    • genetics: Hypersensitivity, Immediate
    • Linkage (Genetics)
    • Research Support, Non-U.S. Gov't
    • genetics: Rhinitis, Allergic, Seasonal


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