Hip fracture and bone histomorphometry in a young adult with cystic fibrosis

C. S. Haworth, A. J. Freemont, A. K. Webb, M. E. Dodd, P. L. Selby, E. B. Mawer, J. E. Adams

    Research output: Contribution to journalArticlepeer-review


    A 25-yr-old male with cystic fibrosis sustained a fragility fracture of the left femoral neck, which required surgical correction. He had several risk factors for the development of low bone density and despite treatment with an oral bisphosphonate, his bone mineral density reduced further. The patient died 2 yrs after sustaining the fracture. Bone specimens obtained at post mortem demonstrated severe cortical and trabecular osteopenia, but the histological features were not typical of osteoporosis or osteomalacia. Osteoporosis is thought to be a common complication of cystic fibrosis. The novel histomorphometric appearances reported here suggest that the bone disease of cystic fibrosis may be more complex and possible unique. Labelled bone biopsies are required to clarify the bone defect leading to low bone density in cystic fibrosis patients so that appropriate therapeutic strategies can be developed.
    Original languageEnglish
    Pages (from-to)478-479
    Number of pages1
    JournalEuropean Respiratory Journal
    Issue number2
    Publication statusPublished - 1999


    • Bone histomorphometry
    • Cystic fibrosis
    • Fracture
    • Low bone density


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