TY - GEN
T1 - Hip fracture discrimination using 3D reconstructions from Dual-energy X-ray Absorptiometry
AU - Whitmarsh, Tristan
AU - Fritscher, Karl D.
AU - Humbert, Ludovic
AU - Del-Rio-Barquero, Luis M.
AU - Schubert, Rainer
AU - Frangi, Alejandro F.
PY - 2011
Y1 - 2011
N2 - Due to the aging of our society, osteoporosis and the subsequent fractures is becoming an increasingly important problem. Currently, Dual-energy X-ray Absortiometry (DXA) derived areal Bone Mineral Density (BMD) is the gold standard for diagnosing osteoporosis, but is limited to a two-dimensional analysis. In this work, we propose a method to discriminate between healthy and fracture patients from DXA images by incorporating a 3D reconstruction method. A statistical model of the 3D shape and BMD distribution was registered onto the DXA scans of fracture and non-fracture patients. The resulting values for the scale and the first model parameter, together with the femoral neck areal BMD, was processed by Linear Discriminant Analysis and the discriminating accuracy was evaluated by generating the Receiver Operating Characteristic curve. The Area Under the Curve using the proposed method was approximately 0.080 and 0.063 higher than using only areal BMD, indicating an improved power of discrimination.
AB - Due to the aging of our society, osteoporosis and the subsequent fractures is becoming an increasingly important problem. Currently, Dual-energy X-ray Absortiometry (DXA) derived areal Bone Mineral Density (BMD) is the gold standard for diagnosing osteoporosis, but is limited to a two-dimensional analysis. In this work, we propose a method to discriminate between healthy and fracture patients from DXA images by incorporating a 3D reconstruction method. A statistical model of the 3D shape and BMD distribution was registered onto the DXA scans of fracture and non-fracture patients. The resulting values for the scale and the first model parameter, together with the femoral neck areal BMD, was processed by Linear Discriminant Analysis and the discriminating accuracy was evaluated by generating the Receiver Operating Characteristic curve. The Area Under the Curve using the proposed method was approximately 0.080 and 0.063 higher than using only areal BMD, indicating an improved power of discrimination.
KW - 3D reconstruction
KW - Bone Mineral Density
KW - Dual-energy X-ray Absortiometry
KW - Fracture risk
KW - Registration
KW - Statistical model
UR - http://www.scopus.com/inward/record.url?scp=80055059013&partnerID=8YFLogxK
U2 - 10.1109/ISBI.2011.5872614
DO - 10.1109/ISBI.2011.5872614
M3 - Conference contribution
AN - SCOPUS:80055059013
SN - 9781424441280
T3 - Proceedings - International Symposium on Biomedical Imaging
SP - 1189
EP - 1192
BT - 2011 8th IEEE International Symposium on Biomedical Imaging
T2 - 2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11
Y2 - 30 March 2011 through 2 April 2011
ER -