HIV Type 1 Diversity in Northeastern Romania in 2000-2001 Based on Phylogenetic Analysis of pol Sequences from Patients Failing Antiretroviral Therapy

Cristian Apetrei; Diane Descamps; Gilles Collin; David L. Robertson; Ivona Pandrea; Petru Groza; Liviu Prisecariu; Irina Teodorescu; Vasile Luca; Françoise Brun-Vézinet

doi:10.1089/088922203771881266

HIV Type 1 Diversity in Northeastern Romania in 2000-2001 Based on Phylogenetic Analysis of pol Sequences from Patients Failing Antiretroviral Therapy

Cristian Apetrei, Diane Descamps, Gilles Collin, David L. Robertson, Ivona Pandrea, Petru Groza, Liviu Prisecariu, Irina Teodorescu, Vasile Luca, Françoise Brun-Vézinet

Research output: Contribution to journal › Article › peer-review

Abstract

Protease and the first half of reverse transcriptase from 71 Romanian patients failing highly active antiretroviral therapy (HAART) have been sequenced and phylogenetically analyzed. These analyses show that 70 patients were infected with subtype F1 and one with subtype C. The pattern of drug resistance mutations in subtype F1-infected patients failing HAART is similar to that described for subtype B strains. These results show that the diversity pattern of HIV type 1 infection in Romania has remained steady over a decade, with subtype F1 remaining the predominant viral form. The circulation of subtype F1 in Romania has the potential to be a source of this HIV-1 subtype in Europe.

Original language	English
Pages (from-to)	1155-1161
Number of pages	6
Journal	AIDS research and human retroviruses
Volume	19
Issue number	12
DOIs	https://doi.org/10.1089/088922203771881266
Publication status	Published - Dec 2003

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Apetrei, C., Descamps, D., Collin, G., Robertson, D. L., Pandrea, I., Groza, P., Prisecariu, L., Teodorescu, I., Luca, V., & Brun-Vézinet, F. (2003). HIV Type 1 Diversity in Northeastern Romania in 2000-2001 Based on Phylogenetic Analysis of pol Sequences from Patients Failing Antiretroviral Therapy. AIDS research and human retroviruses, 19(12), 1155-1161. https://doi.org/10.1089/088922203771881266

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title = "HIV Type 1 Diversity in Northeastern Romania in 2000-2001 Based on Phylogenetic Analysis of pol Sequences from Patients Failing Antiretroviral Therapy",

abstract = "Protease and the first half of reverse transcriptase from 71 Romanian patients failing highly active antiretroviral therapy (HAART) have been sequenced and phylogenetically analyzed. These analyses show that 70 patients were infected with subtype F1 and one with subtype C. The pattern of drug resistance mutations in subtype F1-infected patients failing HAART is similar to that described for subtype B strains. These results show that the diversity pattern of HIV type 1 infection in Romania has remained steady over a decade, with subtype F1 remaining the predominant viral form. The circulation of subtype F1 in Romania has the potential to be a source of this HIV-1 subtype in Europe.",

author = "Cristian Apetrei and Diane Descamps and Gilles Collin and Robertson, {David L.} and Ivona Pandrea and Petru Groza and Liviu Prisecariu and Irina Teodorescu and Vasile Luca and Fran{\c c}oise Brun-V{\'e}zinet",

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Apetrei, C, Descamps, D, Collin, G, Robertson, DL, Pandrea, I, Groza, P, Prisecariu, L, Teodorescu, I, Luca, V & Brun-Vézinet, F 2003, 'HIV Type 1 Diversity in Northeastern Romania in 2000-2001 Based on Phylogenetic Analysis of pol Sequences from Patients Failing Antiretroviral Therapy', AIDS research and human retroviruses, vol. 19, no. 12, pp. 1155-1161. https://doi.org/10.1089/088922203771881266

TY - JOUR

T1 - HIV Type 1 Diversity in Northeastern Romania in 2000-2001 Based on Phylogenetic Analysis of pol Sequences from Patients Failing Antiretroviral Therapy

AU - Apetrei, Cristian

AU - Descamps, Diane

AU - Collin, Gilles

AU - Robertson, David L.

AU - Pandrea, Ivona

AU - Groza, Petru

AU - Prisecariu, Liviu

AU - Teodorescu, Irina

AU - Luca, Vasile

AU - Brun-Vézinet, Françoise

PY - 2003/12

Y1 - 2003/12

N2 - Protease and the first half of reverse transcriptase from 71 Romanian patients failing highly active antiretroviral therapy (HAART) have been sequenced and phylogenetically analyzed. These analyses show that 70 patients were infected with subtype F1 and one with subtype C. The pattern of drug resistance mutations in subtype F1-infected patients failing HAART is similar to that described for subtype B strains. These results show that the diversity pattern of HIV type 1 infection in Romania has remained steady over a decade, with subtype F1 remaining the predominant viral form. The circulation of subtype F1 in Romania has the potential to be a source of this HIV-1 subtype in Europe.

AB - Protease and the first half of reverse transcriptase from 71 Romanian patients failing highly active antiretroviral therapy (HAART) have been sequenced and phylogenetically analyzed. These analyses show that 70 patients were infected with subtype F1 and one with subtype C. The pattern of drug resistance mutations in subtype F1-infected patients failing HAART is similar to that described for subtype B strains. These results show that the diversity pattern of HIV type 1 infection in Romania has remained steady over a decade, with subtype F1 remaining the predominant viral form. The circulation of subtype F1 in Romania has the potential to be a source of this HIV-1 subtype in Europe.

U2 - 10.1089/088922203771881266

DO - 10.1089/088922203771881266

M3 - Article

C2 - 14714572

SN - 0889-2229

VL - 19

SP - 1155

EP - 1161

JO - AIDS research and human retroviruses

JF - AIDS research and human retroviruses

IS - 12

ER -

HIV Type 1 Diversity in Northeastern Romania in 2000-2001 Based on Phylogenetic Analysis of pol Sequences from Patients Failing Antiretroviral Therapy

Abstract

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