TY - JOUR
T1 - HLA antigen and haplotype frequencies in Greeks
AU - Pachoula-Papasteriadis, C.
AU - Ollier, W.
AU - Cutbush, S.
AU - Economidou, J.
AU - Festenstein, H.
N1 - UI - 89284052 LA - eng RN - 0 (HLA Antigens) RN - 0 (HLA-A Antigens) RN - 0 (HLA-B Antigens) PT - Journal Article DA - 19890727 IS - 0001-2815 SB - IM CY - DENMARK
PY - 1989
Y1 - 1989
N2 - A random panel of 189 healthy Greek subjects was HLA typed for A, B and DR antigens. The alleles of these loci were found to be in Hardy-Weinberg equilibrium. Compared with other European Caucasoid populations, the frequencies of A9, B5, B18, B35, DR2 and DR5 were raised and that of B8 lowered. Significant linkage disequilibrium was found between a number of A/B, B/DR and A/DR antigen combinations. Some of the antigen associations usually seen in Caucasoid populations were also present in this sample (A1-B8-DR3, B14-DR1, B15-DR4) although others were missing (A3-B7-DR2, B35-DR1, B44-DR4). In addition, some antigen combinations have not been previously described. The most frequent two locus haplotypes in the Greek population are B8-DR3 and B18-DR5.
AB - A random panel of 189 healthy Greek subjects was HLA typed for A, B and DR antigens. The alleles of these loci were found to be in Hardy-Weinberg equilibrium. Compared with other European Caucasoid populations, the frequencies of A9, B5, B18, B35, DR2 and DR5 were raised and that of B8 lowered. Significant linkage disequilibrium was found between a number of A/B, B/DR and A/DR antigen combinations. Some of the antigen associations usually seen in Caucasoid populations were also present in this sample (A1-B8-DR3, B14-DR1, B15-DR4) although others were missing (A3-B7-DR2, B35-DR1, B44-DR4). In addition, some antigen combinations have not been previously described. The most frequent two locus haplotypes in the Greek population are B8-DR3 and B18-DR5.
KW - ACADEMIC JOURNAL PAPERS
KW - ORIGINAL ARTICLES
M3 - Article
SN - 0001-2815
VL - 33
SP - 488
EP - 490
JO - Tissue Antigens
JF - Tissue Antigens
IS - 4
ER -