HLA-B35 association with nephritis in Henoch-Schönlein purpura

Mahsa M. Amoli, Wendy Thomson, Ali H. Hajeer, Maria C. Calviño, Carlos Garcia-Porrua, William E R Ollier, Miguel A. Gonzalez-Gay

    Research output: Contribution to journalArticlepeer-review


    Objective. To investigate the implications of the HLA-B locus in the susceptibility to Henoch-Schönlein purpura (HSP) and determine if there are associations with renal and gastrointestinal (GI) manifestations of the disease. Methods. A retrospective study was performed on an unselected population of patients with HSP from Northwest Spain. Forty-eight Caucasian patients (24 women), 11 of them older than 20 years, were studied. Patients and ethnically matched controls were HLA-B genotyped from DNA using molecular based methods. Results. When patients with HSP were compared with matched controls, no differences in HLA-B frequencies were observed. No HLA-B associations with GI manifestations were observed. In contrast, an increased frequency of HLA-B35 was observed in patients with renal manifestations (10 of 31) compared to those without (0 of 17). No significant distortions in frequency were seen for any other HLA-B alleles with HSP subgroups. Conclusion. Our results support a role of HLA-B35 in the susceptibility for nephritis in unselected patients with HSP.
    Original languageEnglish
    Pages (from-to)948-949
    Number of pages1
    JournalJournal of Rheumatology
    Issue number5
    Publication statusPublished - 2002


    • Henoch-Schönlein purpura
    • HLA-B
    • Nephritis
    • Renal sequelae


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