TY - JOUR
T1 - HLA class III haplotypes in multicase rheumatoid arthritis families
AU - Fielder, A. H L
AU - Ollier, W.
AU - Lord, D. K.
AU - Burley, M. W.
AU - Silman, A.
AU - Awad, J.
AU - Festenstein, H.
AU - Batchelor, J. R.
N1 - UI - 89291527 LA - eng RN - 0 (HLA Antigens) RN - 0 (Histocompatibility Antigens Class I) RN - 0 (Histocompatibility Antigens Class II) RN - 9007-36-7 (Complement) PT - Journal Article DA - 19890803 IS - 0198-8859 SB - IM CY - UNITED STATES
PY - 1989/6
Y1 - 1989/6
N2 - The class III complement proteins (C2, BF, C4A, and C4B) were studied in 57 multicase rheumatoid arthritis (RA) families. When the gene frequencies for RA probans were compared to a normal control panel (162 haplotypes), a significantly higher frequency of the rare variant C4B*3 was observed (p <0.05). No significant differences were seen for the other C2, BF, C4A, or C4B alleles. The most common haplotype found in the probands was HLA-Cw5, B44, C2*C, BF*S, C4A*3, C4B*3, DR4, occurring with a frequency of 0.088. Haplotypes containing HLA-DR4 and Bw62 were found to carry either C4A*3, C4B*3; C4A*3, C4B*1; or C4A*4,C4B*2. When only haplotypes containing DR4 were compared between probands and controls, the frequency of the C4B*3-bearing haplotype remained higher in the probands. It is concluded that Bw62, C4A*3, C4B*3DR4 is a haplotype which is especially associated with RA. The low frequency in the RA population of this haplotype indicates that C4B*3 has a minor role in overall RA susceptibility. © 1989.
AB - The class III complement proteins (C2, BF, C4A, and C4B) were studied in 57 multicase rheumatoid arthritis (RA) families. When the gene frequencies for RA probans were compared to a normal control panel (162 haplotypes), a significantly higher frequency of the rare variant C4B*3 was observed (p <0.05). No significant differences were seen for the other C2, BF, C4A, or C4B alleles. The most common haplotype found in the probands was HLA-Cw5, B44, C2*C, BF*S, C4A*3, C4B*3, DR4, occurring with a frequency of 0.088. Haplotypes containing HLA-DR4 and Bw62 were found to carry either C4A*3, C4B*3; C4A*3, C4B*1; or C4A*4,C4B*2. When only haplotypes containing DR4 were compared between probands and controls, the frequency of the C4B*3-bearing haplotype remained higher in the probands. It is concluded that Bw62, C4A*3, C4B*3DR4 is a haplotype which is especially associated with RA. The low frequency in the RA population of this haplotype indicates that C4B*3 has a minor role in overall RA susceptibility. © 1989.
KW - ACADEMIC JOURNAL PAPERS
KW - ORIGINAL ARTICLES
M3 - Article
SN - 0198-8859
VL - 25
SP - 75
EP - 85
JO - Human immunology
JF - Human immunology
IS - 2
ER -