HLA-DP does not contribute towards susceptibility to systemic lupus erythematosus

E. J. Davies; C. J. Hutchings; M. C. Hillarby; R. P. Donn; R. G. Cooper; E. M. Hay; R. M. Bernstein; P. J L Holt; D. M. Grennan; W. E R Ollier

HLA-DP does not contribute towards susceptibility to systemic lupus erythematosus

E. J. Davies, C. J. Hutchings, M. C. Hillarby, R. P. Donn, R. G. Cooper, E. M. Hay, R. M. Bernstein, P. J L Holt, D. M. Grennan, W. E R Ollier

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives - To determine whether HLA-DP genes are involved in determining susceptibility to systemic lupus erythematosus (SLE). Methods - HLA-DPA1 and DPB1 genes were amplified by PCR of DNA samples from a panel of patients with SLE and normal controls. Amplified DNA was blotted on to nylon filters and probed with sequence-specific oligonucleotide (SSO) probes. Results - No DPA1 or DPB1 allele was significantly associated with SLE, or with any immunological or clinical subset of SLE. Evidence was found for only limited linkage disequilibrium between HLA-DP and HLA-DQ/DR variants, and none between HLA-DP and the TAP2 gene. Conclusions - These data indicate that HLA-DP genes do not contribute towards determining susceptibility to SLE.

Original language	English
Pages (from-to)	188-190
Number of pages	2
Journal	Annals of the rheumatic diseases
Volume	53
Issue number	3
Publication status	Published - 1994

Keywords

ACADEMIC JOURNAL PAPERS
ORIGINAL ARTICLES

Cite this

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title = "HLA-DP does not contribute towards susceptibility to systemic lupus erythematosus",

abstract = "Objectives - To determine whether HLA-DP genes are involved in determining susceptibility to systemic lupus erythematosus (SLE). Methods - HLA-DPA1 and DPB1 genes were amplified by PCR of DNA samples from a panel of patients with SLE and normal controls. Amplified DNA was blotted on to nylon filters and probed with sequence-specific oligonucleotide (SSO) probes. Results - No DPA1 or DPB1 allele was significantly associated with SLE, or with any immunological or clinical subset of SLE. Evidence was found for only limited linkage disequilibrium between HLA-DP and HLA-DQ/DR variants, and none between HLA-DP and the TAP2 gene. Conclusions - These data indicate that HLA-DP genes do not contribute towards determining susceptibility to SLE.",

keywords = "ACADEMIC JOURNAL PAPERS, ORIGINAL ARTICLES",

author = "Davies, {E. J.} and Hutchings, {C. J.} and Hillarby, {M. C.} and Donn, {R. P.} and Cooper, {R. G.} and Hay, {E. M.} and Bernstein, {R. M.} and Holt, {P. J L} and Grennan, {D. M.} and Ollier, {W. E R}",

note = "UI - 94206102 LA - eng RN - 0 (Autoantibodies) RN - 0 (HLA-DP Antigens) RN - 0 (HLA-DQ Antigens) RN - 0 (HLA-DR Antigens) PT - Journal Article DA - 19940510 IS - 0003-4967 SB - IM CY - ENGLAND",

year = "1994",

language = "English",

volume = "53",

pages = "188--190",

journal = "Annals of the rheumatic diseases",

issn = "0003-4967",

publisher = "BMJ ",

number = "3",

}

TY - JOUR

T1 - HLA-DP does not contribute towards susceptibility to systemic lupus erythematosus

AU - Davies, E. J.

AU - Hutchings, C. J.

AU - Hillarby, M. C.

AU - Donn, R. P.

AU - Cooper, R. G.

AU - Hay, E. M.

AU - Bernstein, R. M.

AU - Holt, P. J L

AU - Grennan, D. M.

AU - Ollier, W. E R

N1 - UI - 94206102 LA - eng RN - 0 (Autoantibodies) RN - 0 (HLA-DP Antigens) RN - 0 (HLA-DQ Antigens) RN - 0 (HLA-DR Antigens) PT - Journal Article DA - 19940510 IS - 0003-4967 SB - IM CY - ENGLAND

PY - 1994

Y1 - 1994

N2 - Objectives - To determine whether HLA-DP genes are involved in determining susceptibility to systemic lupus erythematosus (SLE). Methods - HLA-DPA1 and DPB1 genes were amplified by PCR of DNA samples from a panel of patients with SLE and normal controls. Amplified DNA was blotted on to nylon filters and probed with sequence-specific oligonucleotide (SSO) probes. Results - No DPA1 or DPB1 allele was significantly associated with SLE, or with any immunological or clinical subset of SLE. Evidence was found for only limited linkage disequilibrium between HLA-DP and HLA-DQ/DR variants, and none between HLA-DP and the TAP2 gene. Conclusions - These data indicate that HLA-DP genes do not contribute towards determining susceptibility to SLE.

AB - Objectives - To determine whether HLA-DP genes are involved in determining susceptibility to systemic lupus erythematosus (SLE). Methods - HLA-DPA1 and DPB1 genes were amplified by PCR of DNA samples from a panel of patients with SLE and normal controls. Amplified DNA was blotted on to nylon filters and probed with sequence-specific oligonucleotide (SSO) probes. Results - No DPA1 or DPB1 allele was significantly associated with SLE, or with any immunological or clinical subset of SLE. Evidence was found for only limited linkage disequilibrium between HLA-DP and HLA-DQ/DR variants, and none between HLA-DP and the TAP2 gene. Conclusions - These data indicate that HLA-DP genes do not contribute towards determining susceptibility to SLE.

KW - ACADEMIC JOURNAL PAPERS

KW - ORIGINAL ARTICLES

M3 - Article

SN - 0003-4967

VL - 53

SP - 188

EP - 190

JO - Annals of the rheumatic diseases

JF - Annals of the rheumatic diseases

IS - 3

ER -

HLA-DP does not contribute towards susceptibility to systemic lupus erythematosus

Abstract

Keywords

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