HLA-DP does not contribute towards susceptibility to systemic lupus erythematosus

E. J. Davies; C. J. Hutchings; M. C. Hillarby; R. P. Donn; R. G. Cooper; E. M. Hay; R. M. Bernstein; P. J L Holt; D. M. Grennan; W. E R Ollier

HLA-DP does not contribute towards susceptibility to systemic lupus erythematosus

E. J. Davies
, C. J. Hutchings
, M. C. Hillarby
, R. P. Donn
, R. G. Cooper
, E. M. Hay
, R. M. Bernstein
, P. J L Holt
, D. M. Grennan
, W. E R Ollier

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives - To determine whether HLA-DP genes are involved in determining susceptibility to systemic lupus erythematosus (SLE). Methods - HLA-DPA1 and DPB1 genes were amplified by PCR of DNA samples from a panel of patients with SLE and normal controls. Amplified DNA was blotted on to nylon filters and probed with sequence-specific oligonucleotide (SSO) probes. Results - No DPA1 or DPB1 allele was significantly associated with SLE, or with any immunological or clinical subset of SLE. Evidence was found for only limited linkage disequilibrium between HLA-DP and HLA-DQ/DR variants, and none between HLA-DP and the TAP2 gene. Conclusions - These data indicate that HLA-DP genes do not contribute towards determining susceptibility to SLE.

Original language	English
Pages (from-to)	188-190
Number of pages	2
Journal	Annals of the rheumatic diseases
Volume	53
Issue number	3
Publication status	Published - 1994

Keywords

ACADEMIC JOURNAL PAPERS
ORIGINAL ARTICLES

Cite this

@article{c3fef6697e164677a1e04a175d0d0629,

title = "HLA-DP does not contribute towards susceptibility to systemic lupus erythematosus",

abstract = "Objectives - To determine whether HLA-DP genes are involved in determining susceptibility to systemic lupus erythematosus (SLE). Methods - HLA-DPA1 and DPB1 genes were amplified by PCR of DNA samples from a panel of patients with SLE and normal controls. Amplified DNA was blotted on to nylon filters and probed with sequence-specific oligonucleotide (SSO) probes. Results - No DPA1 or DPB1 allele was significantly associated with SLE, or with any immunological or clinical subset of SLE. Evidence was found for only limited linkage disequilibrium between HLA-DP and HLA-DQ/DR variants, and none between HLA-DP and the TAP2 gene. Conclusions - These data indicate that HLA-DP genes do not contribute towards determining susceptibility to SLE.",

keywords = "ACADEMIC JOURNAL PAPERS, ORIGINAL ARTICLES",

author = "Davies, \{E. J.\} and Hutchings, \{C. J.\} and Hillarby, \{M. C.\} and Donn, \{R. P.\} and Cooper, \{R. G.\} and Hay, \{E. M.\} and Bernstein, \{R. M.\} and Holt, \{P. J L\} and Grennan, \{D. M.\} and Ollier, \{W. E R\}",

note = "UI - 94206102 LA - eng RN - 0 (Autoantibodies) RN - 0 (HLA-DP Antigens) RN - 0 (HLA-DQ Antigens) RN - 0 (HLA-DR Antigens) PT - Journal Article DA - 19940510 IS - 0003-4967 SB - IM CY - ENGLAND",

year = "1994",

language = "English",

volume = "53",

pages = "188--190",

journal = "Annals of the rheumatic diseases",

issn = "0003-4967",

publisher = "Elsevier BV",

number = "3",

}

TY - JOUR

T1 - HLA-DP does not contribute towards susceptibility to systemic lupus erythematosus

AU - Davies, E. J.

AU - Hutchings, C. J.

AU - Hillarby, M. C.

AU - Donn, R. P.

AU - Cooper, R. G.

AU - Hay, E. M.

AU - Bernstein, R. M.

AU - Holt, P. J L

AU - Grennan, D. M.

AU - Ollier, W. E R

N1 - UI - 94206102 LA - eng RN - 0 (Autoantibodies) RN - 0 (HLA-DP Antigens) RN - 0 (HLA-DQ Antigens) RN - 0 (HLA-DR Antigens) PT - Journal Article DA - 19940510 IS - 0003-4967 SB - IM CY - ENGLAND

PY - 1994

Y1 - 1994

N2 - Objectives - To determine whether HLA-DP genes are involved in determining susceptibility to systemic lupus erythematosus (SLE). Methods - HLA-DPA1 and DPB1 genes were amplified by PCR of DNA samples from a panel of patients with SLE and normal controls. Amplified DNA was blotted on to nylon filters and probed with sequence-specific oligonucleotide (SSO) probes. Results - No DPA1 or DPB1 allele was significantly associated with SLE, or with any immunological or clinical subset of SLE. Evidence was found for only limited linkage disequilibrium between HLA-DP and HLA-DQ/DR variants, and none between HLA-DP and the TAP2 gene. Conclusions - These data indicate that HLA-DP genes do not contribute towards determining susceptibility to SLE.

AB - Objectives - To determine whether HLA-DP genes are involved in determining susceptibility to systemic lupus erythematosus (SLE). Methods - HLA-DPA1 and DPB1 genes were amplified by PCR of DNA samples from a panel of patients with SLE and normal controls. Amplified DNA was blotted on to nylon filters and probed with sequence-specific oligonucleotide (SSO) probes. Results - No DPA1 or DPB1 allele was significantly associated with SLE, or with any immunological or clinical subset of SLE. Evidence was found for only limited linkage disequilibrium between HLA-DP and HLA-DQ/DR variants, and none between HLA-DP and the TAP2 gene. Conclusions - These data indicate that HLA-DP genes do not contribute towards determining susceptibility to SLE.

KW - ACADEMIC JOURNAL PAPERS

KW - ORIGINAL ARTICLES

M3 - Article

SN - 0003-4967

VL - 53

SP - 188

EP - 190

JO - Annals of the rheumatic diseases

JF - Annals of the rheumatic diseases

IS - 3

ER -

HLA-DP does not contribute towards susceptibility to systemic lupus erythematosus

Abstract

Keywords

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