HLA-DRB1 status affects endothelial function in treated patients with rheumatoid arthritis

Carlos Gonzalez-Juanatey; Ana Testa; Alberto Garcia-Castelo; Carlos Garcia-Porrua; Javier Llorca; Juan Vidan; Ali H. Hajeer; William E. Ollier; Derek L. Mattey; Miguel A. Gonzalez-Gay

doi:10.1016/S0002-9343(03)00133-5

HLA-DRB1 status affects endothelial function in treated patients with rheumatoid arthritis

Carlos Gonzalez-Juanatey, Ana Testa, Alberto Garcia-Castelo, Carlos Garcia-Porrua, Javier Llorca, Juan Vidan, Ali H. Hajeer, William E. Ollier, Derek L. Mattey, Miguel A. Gonzalez-Gay

Research output: Contribution to journal › Article › peer-review

Abstract

PURPOSE: To examine endothelial function in rheumatoid arthritis patients and to assess whether clinical or genetic factors affect the development of endothelial dysfunction. METHODS: Fifty-five patients fulfilling the 1987 American College of Rheumatology classification criteria for rheumatoid arthritis were recruited from Hospital Xeral-Calde, Lugo, Spain. Patients were required to have been treated for at least 5 years, including current treatment with one or more disease-modifying antirheumatic drugs. Patients with diabetes mellitus, renal insufficiency, or cardiovascular disease were excluded. Thirty-one age-, sex-, and ethnically matched controls were also studied. Endothelium-dependent (postischemia) and -independent (postnitroglycerin) vasodilatation were measured by brachial ultrasonography. Patients were genotyped for human leukocyte antigen (HLA)-DRB1. RESULTS: Patients had decreased endothelium-dependent vasodilatation (mean [± SD], 3.8% ± 4.9%) compared with controls (8.0% ± 4.5%; P

Original language	English
Pages (from-to)	647-652
Number of pages	5
Journal	The American Journal of Medicine
Volume	114
Issue number	8
DOIs	https://doi.org/10.1016/S0002-9343(03)00133-5
Publication status	Published - 1 Jun 2003

Keywords

Adult
Aged
Alleles
Arthritis
Arthritis,Rheumatoid
classification
Diabetes Mellitus
Disease
Endothelium,Vascular
Female
Genetic Predisposition to Disease
genetics
Genotype
Histocompatibility Testing
HLA-DR Antigens
Human
Male
methods
Middle Age
physiopathology
Rheumatology
Risk
Spain
ultrasonography
Vasodilation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0002-9343(03)00133-5

Cite this

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title = "HLA-DRB1 status affects endothelial function in treated patients with rheumatoid arthritis",

abstract = "PURPOSE: To examine endothelial function in rheumatoid arthritis patients and to assess whether clinical or genetic factors affect the development of endothelial dysfunction. METHODS: Fifty-five patients fulfilling the 1987 American College of Rheumatology classification criteria for rheumatoid arthritis were recruited from Hospital Xeral-Calde, Lugo, Spain. Patients were required to have been treated for at least 5 years, including current treatment with one or more disease-modifying antirheumatic drugs. Patients with diabetes mellitus, renal insufficiency, or cardiovascular disease were excluded. Thirty-one age-, sex-, and ethnically matched controls were also studied. Endothelium-dependent (postischemia) and -independent (postnitroglycerin) vasodilatation were measured by brachial ultrasonography. Patients were genotyped for human leukocyte antigen (HLA)-DRB1. RESULTS: Patients had decreased endothelium-dependent vasodilatation (mean [± SD], 3.8% ± 4.9%) compared with controls (8.0% ± 4.5%; P",

keywords = "Adult, Aged, Alleles, Arthritis, Arthritis,Rheumatoid, classification, Diabetes Mellitus, Disease, Endothelium,Vascular, Female, Genetic Predisposition to Disease, genetics, Genotype, Histocompatibility Testing, HLA-DR Antigens, Human, Male, methods, Middle Age, physiopathology, Rheumatology, Risk, Spain, ultrasonography, Vasodilation",

author = "Carlos Gonzalez-Juanatey and Ana Testa and Alberto Garcia-Castelo and Carlos Garcia-Porrua and Javier Llorca and Juan Vidan and Hajeer, {Ali H.} and Ollier, {William E.} and Mattey, {Derek L.} and Gonzalez-Gay, {Miguel A.}",

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journal = "The American Journal of Medicine",

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TY - JOUR

T1 - HLA-DRB1 status affects endothelial function in treated patients with rheumatoid arthritis

AU - Gonzalez-Juanatey, Carlos

AU - Testa, Ana

AU - Garcia-Castelo, Alberto

AU - Garcia-Porrua, Carlos

AU - Llorca, Javier

AU - Vidan, Juan

AU - Hajeer, Ali H.

AU - Ollier, William E.

AU - Mattey, Derek L.

AU - Gonzalez-Gay, Miguel A.

N1 - UI - 22682495DA - 20030611IS - 0002-9343LA - engPT - Journal ArticleRN - 0 (HLA-DR Antigens)RN - 128338-86-3 (HLA-DRB1)SB - AIMSB - IM

PY - 2003/6/1

Y1 - 2003/6/1

N2 - PURPOSE: To examine endothelial function in rheumatoid arthritis patients and to assess whether clinical or genetic factors affect the development of endothelial dysfunction. METHODS: Fifty-five patients fulfilling the 1987 American College of Rheumatology classification criteria for rheumatoid arthritis were recruited from Hospital Xeral-Calde, Lugo, Spain. Patients were required to have been treated for at least 5 years, including current treatment with one or more disease-modifying antirheumatic drugs. Patients with diabetes mellitus, renal insufficiency, or cardiovascular disease were excluded. Thirty-one age-, sex-, and ethnically matched controls were also studied. Endothelium-dependent (postischemia) and -independent (postnitroglycerin) vasodilatation were measured by brachial ultrasonography. Patients were genotyped for human leukocyte antigen (HLA)-DRB1. RESULTS: Patients had decreased endothelium-dependent vasodilatation (mean [± SD], 3.8% ± 4.9%) compared with controls (8.0% ± 4.5%; P

AB - PURPOSE: To examine endothelial function in rheumatoid arthritis patients and to assess whether clinical or genetic factors affect the development of endothelial dysfunction. METHODS: Fifty-five patients fulfilling the 1987 American College of Rheumatology classification criteria for rheumatoid arthritis were recruited from Hospital Xeral-Calde, Lugo, Spain. Patients were required to have been treated for at least 5 years, including current treatment with one or more disease-modifying antirheumatic drugs. Patients with diabetes mellitus, renal insufficiency, or cardiovascular disease were excluded. Thirty-one age-, sex-, and ethnically matched controls were also studied. Endothelium-dependent (postischemia) and -independent (postnitroglycerin) vasodilatation were measured by brachial ultrasonography. Patients were genotyped for human leukocyte antigen (HLA)-DRB1. RESULTS: Patients had decreased endothelium-dependent vasodilatation (mean [± SD], 3.8% ± 4.9%) compared with controls (8.0% ± 4.5%; P

KW - Adult

KW - Aged

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KW - Endothelium,Vascular

KW - Female

KW - Genetic Predisposition to Disease

KW - genetics

KW - Genotype

KW - Histocompatibility Testing

KW - HLA-DR Antigens

KW - Human

KW - Male

KW - methods

KW - Middle Age

KW - physiopathology

KW - Rheumatology

KW - Risk

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KW - ultrasonography

KW - Vasodilation

U2 - 10.1016/S0002-9343(03)00133-5

DO - 10.1016/S0002-9343(03)00133-5

M3 - Article

SN - 1555-7162

VL - 114

SP - 647

EP - 652

JO - The American Journal of Medicine

JF - The American Journal of Medicine

IS - 8

ER -

HLA-DRB1 status affects endothelial function in treated patients with rheumatoid arthritis

Abstract

Keywords

UN SDGs

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