HLA-DRB*1501 Associations with Magnetic Resonance Imaging Measures of Grey Matter Pathology in Multiple Sclerosis

Özgür Yaldizli; Varun Sethi; Matteo Pardini; Carmen Tur; Kin Y Mok; Nils Muhlert; Zheng Liu; Rebecca S Samson; Claudia AM Wheeler-Kingshott; Tarek Yousry; Henry Houlden; John Hardy; David Miller; Declan Chard

doi:10.1016/j.msard.2016.03.003

HLA-DRB*1501 Associations with Magnetic Resonance Imaging Measures of Grey Matter Pathology in Multiple Sclerosis

Özgür Yaldizli, Varun Sethi, Matteo Pardini, Carmen Tur, Kin Y Mok, Nils Muhlert, Zheng Liu, Rebecca S Samson, Claudia AM Wheeler-Kingshott, Tarek Yousry, Henry Houlden, John Hardy, David Miller, Declan Chard

Research output: Contribution to journal › Article › peer-review

Abstract

Background The HLA-DRB⁎1501 haplotype influences the risk of developing multiple sclerosis (MS), but it is not known how it affects grey matter pathology. Aim To assess HLA-DRB⁎1501 effects on magnetic resonance imaging (MRI) cortical grey matter pathology. Methods Whole and lesional cortical grey matter volumes, lesional and normal-appearing grey matter magnetization transfer ratio were measured in 85 people with MS and 36 healthy control subjects. HLA-DRB⁎1501 haplotype was determined by genotyping (rs3135388). Results No significant differences were observed in MRI measures between the HLA-DRB⁎1501 subgroups. Conclusions The HLA-DRB⁎1501 haplotype is not strongly associated with MRI-visible grey matter pathology.

Original language	English
Journal	Multiple sclerosis and related disorders
Early online date	7 Mar 2016
DOIs	https://doi.org/10.1016/j.msard.2016.03.003
Publication status	Published - May 2016

Keywords

Multiple sclerosis; gray matter; magnetization transfer ratio; HLA-DRB⁎1501; cortical lesion

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10.1016/j.msard.2016.03.003

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Yaldizli, Ö., Sethi, V., Pardini, M., Tur, C., Mok, K. Y., Muhlert, N., Liu, Z., Samson, R. S., Wheeler-Kingshott, C. AM., Yousry, T., Houlden, H., Hardy, J., Miller, D., & Chard, D. (2016). HLA-DRB*1501 Associations with Magnetic Resonance Imaging Measures of Grey Matter Pathology in Multiple Sclerosis. Multiple sclerosis and related disorders. https://doi.org/10.1016/j.msard.2016.03.003

@article{89653ed689444dc48107f79061867db7,

title = "HLA-DRB*1501 Associations with Magnetic Resonance Imaging Measures of Grey Matter Pathology in Multiple Sclerosis",

abstract = "Background The HLA-DRB⁎1501 haplotype influences the risk of developing multiple sclerosis (MS), but it is not known how it affects grey matter pathology. Aim To assess HLA-DRB⁎1501 effects on magnetic resonance imaging (MRI) cortical grey matter pathology. Methods Whole and lesional cortical grey matter volumes, lesional and normal-appearing grey matter magnetization transfer ratio were measured in 85 people with MS and 36 healthy control subjects. HLA-DRB⁎1501 haplotype was determined by genotyping (rs3135388). Results No significant differences were observed in MRI measures between the HLA-DRB⁎1501 subgroups. Conclusions The HLA-DRB⁎1501 haplotype is not strongly associated with MRI-visible grey matter pathology.",

keywords = "Multiple sclerosis; gray matter; magnetization transfer ratio; HLA-DRB⁎1501; cortical lesion",

author = "{\"O}zg{\"u}r Yaldizli and Varun Sethi and Matteo Pardini and Carmen Tur and Mok, {Kin Y} and Nils Muhlert and Zheng Liu and Samson, {Rebecca S} and Wheeler-Kingshott, {Claudia AM} and Tarek Yousry and Henry Houlden and John Hardy and David Miller and Declan Chard",

year = "2016",

month = may,

doi = "10.1016/j.msard.2016.03.003",

language = "English",

journal = "Multiple sclerosis and related disorders",

issn = "2211-0356",

publisher = "Elsevier BV",

}

Yaldizli, Ö, Sethi, V, Pardini, M, Tur, C, Mok, KY, Muhlert, N, Liu, Z, Samson, RS, Wheeler-Kingshott, CAM, Yousry, T, Houlden, H, Hardy, J, Miller, D & Chard, D 2016, 'HLA-DRB*1501 Associations with Magnetic Resonance Imaging Measures of Grey Matter Pathology in Multiple Sclerosis', Multiple sclerosis and related disorders. https://doi.org/10.1016/j.msard.2016.03.003

TY - JOUR

T1 - HLA-DRB*1501 Associations with Magnetic Resonance Imaging Measures of Grey Matter Pathology in Multiple Sclerosis

AU - Yaldizli, Özgür

AU - Sethi, Varun

AU - Pardini, Matteo

AU - Tur, Carmen

AU - Mok, Kin Y

AU - Muhlert, Nils

AU - Liu, Zheng

AU - Samson, Rebecca S

AU - Wheeler-Kingshott, Claudia AM

AU - Yousry, Tarek

AU - Houlden, Henry

AU - Hardy, John

AU - Miller, David

AU - Chard, Declan

PY - 2016/5

Y1 - 2016/5

N2 - Background The HLA-DRB⁎1501 haplotype influences the risk of developing multiple sclerosis (MS), but it is not known how it affects grey matter pathology. Aim To assess HLA-DRB⁎1501 effects on magnetic resonance imaging (MRI) cortical grey matter pathology. Methods Whole and lesional cortical grey matter volumes, lesional and normal-appearing grey matter magnetization transfer ratio were measured in 85 people with MS and 36 healthy control subjects. HLA-DRB⁎1501 haplotype was determined by genotyping (rs3135388). Results No significant differences were observed in MRI measures between the HLA-DRB⁎1501 subgroups. Conclusions The HLA-DRB⁎1501 haplotype is not strongly associated with MRI-visible grey matter pathology.

AB - Background The HLA-DRB⁎1501 haplotype influences the risk of developing multiple sclerosis (MS), but it is not known how it affects grey matter pathology. Aim To assess HLA-DRB⁎1501 effects on magnetic resonance imaging (MRI) cortical grey matter pathology. Methods Whole and lesional cortical grey matter volumes, lesional and normal-appearing grey matter magnetization transfer ratio were measured in 85 people with MS and 36 healthy control subjects. HLA-DRB⁎1501 haplotype was determined by genotyping (rs3135388). Results No significant differences were observed in MRI measures between the HLA-DRB⁎1501 subgroups. Conclusions The HLA-DRB⁎1501 haplotype is not strongly associated with MRI-visible grey matter pathology.

KW - Multiple sclerosis; gray matter; magnetization transfer ratio; HLA-DRB⁎1501; cortical lesion

U2 - 10.1016/j.msard.2016.03.003

DO - 10.1016/j.msard.2016.03.003

M3 - Article

SN - 2211-0356

JO - Multiple sclerosis and related disorders

JF - Multiple sclerosis and related disorders

ER -

HLA-DRB*1501 Associations with Magnetic Resonance Imaging Measures of Grey Matter Pathology in Multiple Sclerosis

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Keywords

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