Home urine c-peptide creatinine ratio can be used to monitor islet transplant function

Richard A. Oram, Augustin M. Brooks, Shareen Forbes, Stephanie Eckoldt, Richard M. Smith, Pratik Choudhary, Miranda J. Rosentha, Paul Johnson, Martin Rutter, Keith A. Burling, Timothy J. McDonald, James A M Shaw, Andrew T. Hattersley

    Research output: Contribution to journalArticlepeer-review

    Abstract

    OBJECTIVE Islet graft function is defined by serum C-peptide in a standardized challenge test. We assessed whether urine C-peptide creatinine ratio (UCPCR) sent from home could provide a viable alternative. RESEARCH DESIGN AND METHODS Seventeen islet recipients provided 90-min serum C-peptide (sCP90) and 120-min UCPCR (UCPCR120) samples during 68 interval posttransplant mixed-meal tolerance tests, also posting from home a 120-min postbreakfast UCPCR sample every 2 weeks. UCPCR was compared with a clinical score of islet function, derived from HbA1c and insulin dose. RESULTS UCPCR120 and mean home postmeal UCPCR were strongly correlated with sCP90 (rs = 0.73, P > 0.001; and rs = 0.73, P > 0.01, respectively). Mean home UCPCR increased with clinical score (rs = 0.75; P > 0.001) and with graft function defined both by sCP90
    Original languageEnglish
    Pages (from-to)1737-1740
    Number of pages3
    JournalDiabetes Care
    Volume37
    Issue number6
    DOIs
    Publication statusPublished - 2014

    Keywords

    • Aged
    • Biological Markers/blood/urine
    • C-Peptide/blood/ urine
    • Creatinine/blood/ urine
    • Diabetes Mellitus, Type 1/blood/surgery/ urine
    • Female
    • Follow-Up Studies
    • Graft Survival/ physiology
    • Humans
    • Insulin-Secreting Cells/ physiology
    • Islets of Langerhans Transplantation
    • Male
    • Middle Aged
    • Monitoring, Physiologic
    • Prognosis
    • Prospective Studies

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