Horizontal gene transfer depends on gene content of the host

Csaba Pál; Balázs Papp; Martin J. Lercher

doi:10.1093/bioinformatics/bti1136

Horizontal gene transfer depends on gene content of the host

Csaba Pál, Balázs Papp, Martin J. Lercher

Research output: Contribution to journal › Article › peer-review

Abstract

Horizontal gene transfer is a major contributor to the evolution of bacterial genomes. We examine this process through a combination of comparative genomics and in silico analysis of the Escherichia coli metabolic network. We validate our horizontal transfer estimates by confirming the predicted gradual amelioration of GC content over time. We find that the chance of acquiring a gene by horizontal transfer is up to six times higher if an enzyme that catalyses a coupled metabolite flux is already encoded in the host genome. © The Author 2005. Published by Oxford University Press. All rights reserved.

Original language	English
Pages (from-to)	222-223
Number of pages	1
Journal	Bioinformatics
Volume	21
Issue number	2
DOIs	https://doi.org/10.1093/bioinformatics/bti1136
Publication status	Published - Sept 2005

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title = "Horizontal gene transfer depends on gene content of the host",

abstract = "Horizontal gene transfer is a major contributor to the evolution of bacterial genomes. We examine this process through a combination of comparative genomics and in silico analysis of the Escherichia coli metabolic network. We validate our horizontal transfer estimates by confirming the predicted gradual amelioration of GC content over time. We find that the chance of acquiring a gene by horizontal transfer is up to six times higher if an enzyme that catalyses a coupled metabolite flux is already encoded in the host genome. {\textcopyright} The Author 2005. Published by Oxford University Press. All rights reserved.",

author = "Csaba P{\'a}l and Bal{\'a}zs Papp and Lercher, {Martin J.}",

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AB - Horizontal gene transfer is a major contributor to the evolution of bacterial genomes. We examine this process through a combination of comparative genomics and in silico analysis of the Escherichia coli metabolic network. We validate our horizontal transfer estimates by confirming the predicted gradual amelioration of GC content over time. We find that the chance of acquiring a gene by horizontal transfer is up to six times higher if an enzyme that catalyses a coupled metabolite flux is already encoded in the host genome. © The Author 2005. Published by Oxford University Press. All rights reserved.

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DO - 10.1093/bioinformatics/bti1136

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Horizontal gene transfer depends on gene content of the host

Abstract

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