Hormonal response to L-tryptophan infusion: effect of propranolol

A K Upadhyaya, J F Deakin, I Pennell

Research output: Contribution to journalArticlepeer-review

Abstract

There is circumstantial evidence that increases in prolactin secretion evoked by L-tryptophan infusion involve 5-HT1 receptors, whereas growth hormone responses do not. Propranolol is a beta-adrenoceptor antagonist that also possesses antagonist properties at 5-HT1 receptors. Propranolol (80 mg, PO) failed to attenuate the prolactin response to L-tryptophan infusion (100 mg/kg, IV) in seven volunteers; the role of 5-HT1 receptors in this response remains uncertain. The growth hormone response to tryptophan was enhanced by propranolol, consistent with previous reports of an inhibitory beta-adrenoceptor influence on GH secretion. Excessive beta-adrenoceptor function might explain the blunted growth hormone response to tryptophan in depression.

Original languageEnglish
Pages (from-to)309-12
Number of pages4
JournalPsychoneuroendocrinology
Volume15
Issue number4
DOIs
Publication statusPublished - 1990

Keywords

  • Adult
  • Arousal
  • Growth Hormone
  • Humans
  • Infusions, Intravenous
  • Male
  • Prolactin
  • Propranolol
  • Receptors, Serotonin
  • Tryptophan
  • Journal Article

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