How do common chronic conditions affect health-related quality of life?

I. T M Heyworth, Michelle L. Hazell, Mary F. Linehan, Timothy L. Frank

    Research output: Contribution to journalArticlepeer-review


    Background: Comorbidity is common. National Institute for Health and Clinical Excellence (NICE) guidelines have been created to make best use of resources to improve patients' quality of life but do not currently take account of comorbidity. The effect of multiple chronic conditions with regard to health-related quality of life (HRQoL) is poorly researched. Criticisms of previous research have been due to patient-defined chronic conditions, lack of quantification of the effects of confounding factors, selection of affected patients only, small sample sizes, and upper age limits. Aim: This study aims to address these issues, looking into the impact of combinations of chronic conditions on HRQoL. Design of study: Participants filled in a questionnaire containing general health information, specific respiratory questions, and the EQ-5D measure of HRQoL. The questionnaires were then matched up to their GP records to obtain their disease status for six common chronic diseases (asthma, chronic obstructive pulmonary disease, ischaemic heart disease, hypertension, diabetes, and cerebrovascular disease). Setting: UK general practice. Method: Data from a mailed questionnaire were analysed from 5169 patients aged >16 years from two general practices in Wythenshawe, Manchester in 2004. Completion of the questionnaire was taken to indicate consent to participate. Results: Significant correlations were found between a lower HRQoL and increasing numbers of chronic conditions (P
    Original languageEnglish
    Pages (from-to)833-838
    Number of pages5
    JournalBritish Journal of General Practice
    Issue number568
    Publication statusPublished - Nov 2009


    • Chronic disease
    • Comorbidity
    • EQ-5D
    • Health related quality of life


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