How integrins control breast biology

Marina A. Glukhova; Charles H. Streuli

doi:10.1016/j.ceb.2013.06.010

How integrins control breast biology

Research output: Contribution to journal › Article › peer-review

Abstract

This article explores new ideas about how the ECM-integrin axis controls normal and malignant breast biology. We discuss the role of integrins in mammary stem cells, and how cell-matrix interactions regulate ductal and alveolar development and function. We also examine the contribution of integrins to tissue disorganisation and metastasis, and how an altered stromal and ECM tumour microenvironment affects the cancer cell niche both within primary tumours and at distant sites. Finally, we mention novel strategies for integrin-directed breast cancer treatment. © 2013 The Authors.

Original language	English
Pages (from-to)	633-641
Number of pages	8
Journal	Current opinion in cell biology
Volume	25
Issue number	5
DOIs	https://doi.org/10.1016/j.ceb.2013.06.010
Publication status	Published - Oct 2013

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title = "How integrins control breast biology",

abstract = "This article explores new ideas about how the ECM-integrin axis controls normal and malignant breast biology. We discuss the role of integrins in mammary stem cells, and how cell-matrix interactions regulate ductal and alveolar development and function. We also examine the contribution of integrins to tissue disorganisation and metastasis, and how an altered stromal and ECM tumour microenvironment affects the cancer cell niche both within primary tumours and at distant sites. Finally, we mention novel strategies for integrin-directed breast cancer treatment. {\textcopyright} 2013 The Authors.",

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AU - Streuli, Charles H.

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AB - This article explores new ideas about how the ECM-integrin axis controls normal and malignant breast biology. We discuss the role of integrins in mammary stem cells, and how cell-matrix interactions regulate ductal and alveolar development and function. We also examine the contribution of integrins to tissue disorganisation and metastasis, and how an altered stromal and ECM tumour microenvironment affects the cancer cell niche both within primary tumours and at distant sites. Finally, we mention novel strategies for integrin-directed breast cancer treatment. © 2013 The Authors.

U2 - 10.1016/j.ceb.2013.06.010

DO - 10.1016/j.ceb.2013.06.010

M3 - Article

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VL - 25

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EP - 641

JO - Current opinion in cell biology

JF - Current opinion in cell biology

IS - 5

ER -

How integrins control breast biology

Abstract

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