How integrins control breast biology

Marina A. Glukhova, Charles H. Streuli

    Research output: Contribution to journalArticlepeer-review


    This article explores new ideas about how the ECM-integrin axis controls normal and malignant breast biology. We discuss the role of integrins in mammary stem cells, and how cell-matrix interactions regulate ductal and alveolar development and function. We also examine the contribution of integrins to tissue disorganisation and metastasis, and how an altered stromal and ECM tumour microenvironment affects the cancer cell niche both within primary tumours and at distant sites. Finally, we mention novel strategies for integrin-directed breast cancer treatment. © 2013 The Authors.
    Original languageEnglish
    Pages (from-to)633-641
    Number of pages8
    JournalCurrent opinion in cell biology
    Issue number5
    Publication statusPublished - Oct 2013


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