How participants in cancer trials are chosen: Ethics and conflicting interests

Gordon Jayson; John Harris

doi:10.1038/nrc1842

How participants in cancer trials are chosen: Ethics and conflicting interests

Gordon Jayson
, John Harris

Research output: Contribution to journal › Article › peer-review

Abstract

The development of new drugs for cancer is extremely complex and expensive, and poses ethical problems. In this article we will review issues in clinical trials for cancer drugs that will cast new light on the doctor-patient relationship and their interaction with industry, the health service, academic and administrative organizations. We show that the Declaration of Helsinki cannot be applied to cancer trials as it is currently written, that patients do not and perhaps cannot give fully informed consent to participate, and that the results of clinical trials do not translate into daily practice in a way that patients might expect. © 2006 Nature Publishing Group.

Original language	English
Pages (from-to)	330-336
Number of pages	6
Journal	Nature Reviews Cancer
Volume	6
Issue number	4
DOIs	https://doi.org/10.1038/nrc1842
Publication status	Published - Apr 2006

Keywords

*Clinical Trials as Topic
*Conflict of Interest
*Ethics, Medical
Humans
Neoplasms/*therapy
*Patient Selection

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nrc1842

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16557284

Cite this

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title = "How participants in cancer trials are chosen: Ethics and conflicting interests",

abstract = "The development of new drugs for cancer is extremely complex and expensive, and poses ethical problems. In this article we will review issues in clinical trials for cancer drugs that will cast new light on the doctor-patient relationship and their interaction with industry, the health service, academic and administrative organizations. We show that the Declaration of Helsinki cannot be applied to cancer trials as it is currently written, that patients do not and perhaps cannot give fully informed consent to participate, and that the results of clinical trials do not translate into daily practice in a way that patients might expect. {\textcopyright} 2006 Nature Publishing Group.",

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author = "Gordon Jayson and John Harris",

note = "Jayson, Gordon Harris, John Review England Nature reviews. Cancer Nat Rev Cancer. 2006 Apr;6(4):330-6.",

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AB - The development of new drugs for cancer is extremely complex and expensive, and poses ethical problems. In this article we will review issues in clinical trials for cancer drugs that will cast new light on the doctor-patient relationship and their interaction with industry, the health service, academic and administrative organizations. We show that the Declaration of Helsinki cannot be applied to cancer trials as it is currently written, that patients do not and perhaps cannot give fully informed consent to participate, and that the results of clinical trials do not translate into daily practice in a way that patients might expect. © 2006 Nature Publishing Group.

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KW - Neoplasms/therapy

KW - Patient Selection

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How participants in cancer trials are chosen: Ethics and conflicting interests

Abstract

Keywords

UN SDGs

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Cite this